| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| 100mg |
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| Other Sizes |
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| ln Vivo |
RLX-33 (10 mg/kg; IP, single dose) attenuates the increase in food intake elicited by the RXFP3 selective agonist R3/I5 in male Wistar rats [1]. RLX-33 (10 mg/kg; IP, single dose) displays strong brain penetration and high protein binding in rat plasma [1]. Pharmacokinetic characteristics of RLX-33 in male Wistar rats (IP, 10 mg/kg) [1]. Brain plasma Cmax (ng/mL) 1401 1552 tmax (h) 0.5 2.0 t1/2 (h) 1.9 4.9 AUCinf (ng/mL·h) 5352 12519 CL_F (mL/min/kg) 43.8
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|---|---|
| Animal Protocol |
Animal/Disease Models: Male Wistar rat (Intracerebroventricular injection of R3/I5 stimulates food intake [1]
Doses: 10 mg/kg Route of Administration: IP, single dose Experimental Results: attenuates R3/I5-induced increase in food intake Animal/Disease Models: Male Wistar rat [1] Doses: 10 mg/kg Doses: IP, single dose (pharmacokinetic/PK/PK analysis) Experimental Results: It demonstrated good brain penetration and high protein binding, and the protein binding rate in rat plasma was 99.8%. |
| References |
| Molecular Formula |
C24H19CLN4O4
|
|---|---|
| Molecular Weight |
462.88506436348
|
| Exact Mass |
462.109
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| CAS # |
2784577-71-3
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| PubChem CID |
164886639
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| Appearance |
White to light yellow solid powder
|
| LogP |
3
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
33
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| Complexity |
696
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| Defined Atom Stereocenter Count |
0
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| SMILES |
N1(CC2=CC=CO2)C(=O)CC(C(NC2=CC=C(C3ON=C(C4=CC=C(Cl)C=C4)N=3)C=C2)=O)C1
|
| InChi Key |
LTOAWFRZXVPHAJ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C24H19ClN4O4/c25-18-7-3-15(4-8-18)22-27-24(33-28-22)16-5-9-19(10-6-16)26-23(31)17-12-21(30)29(13-17)14-20-2-1-11-32-20/h1-11,17H,12-14H2,(H,26,31)
|
| Chemical Name |
N-[4-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]phenyl]-1-(furan-2-ylmethyl)-5-oxopyrrolidine-3-carboxamide
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~270.04 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.49 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1603 mL | 10.8017 mL | 21.6034 mL | |
| 5 mM | 0.4321 mL | 2.1603 mL | 4.3207 mL | |
| 10 mM | 0.2160 mL | 1.0802 mL | 2.1603 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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