| Size | Price | Stock | Qty |
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| 5mg |
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Purity: ≥98%
RU-24,969 is a novel, potent and selective agonist of the 5-HT1A and 5-HT1B receptors. RU-24,969 was found to increase the reinforcing properties of cocaine, suggesting a role for 5-HT1B receptors in cocaine addiction.
| ln Vitro |
In vitro, RU 24969 (10 μM) decreases K+-stimulated [3H]-5-HT release in rat frontal brain slices [2].
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| ln Vivo |
In dehydrated rats, RU 24969 (0.03–3.0 mg/kg; subcutaneous injection) decreases water consumption in a dose-dependent manner [1]. Subcutaneous injection of RU 24969 (0.3–3.0 mg/kg) enhances forward motility in a dose-dependent manner [1].
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| Animal Protocol |
Animal/Disease Models: Male SD (SD (Sprague-Dawley)) rat[1]
Doses: 0.03, 0.3, 1.0, 3.0 mg/kg Route of Administration: Single subcutaneous injection Experimental Results: Water consumption was Dramatically diminished at doses of 0.3, 1.0 and 3.0 mg/kg . |
| References |
[1]. Aronsen D, et, al. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep; 124: 1-4.
[2]. Brazell MP, et, al. The 5-HT1 receptor agonist RU-24969 decreases 5-hydroxytryptamine (5-HT) release and metabolism in the rat frontal cortex in vitro and in vivo. Br J Pharmacol. 1985 Sep; 86(1): 209-16. |
| Molecular Formula |
C14H16N2OM
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|---|---|
| Molecular Weight |
228.3
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| Exact Mass |
228.1263
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| Elemental Analysis |
C, 73.66; H, 7.06; N, 12.27; O, 7.01
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| CAS # |
66611-26-5
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| Related CAS # |
RU 24969 succinate;107008-28-6;RU 24969 hemisuccinate;66611-27-6
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| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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| SMILES |
COC1=CC2=C(NC=C2C3=CCNCC3)C=C1
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| InChi Key |
KRVMLPUDAOWOGN-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3
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| Chemical Name |
5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole hemisuccinate
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| Synonyms |
RU 24,969 RU-24,969 RU24,969RU 24969 RU-24969 RU24969
RU 24969 hemisuccinate RU 24969 RU-24969 RU24969.
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 30 mg/mL (~131.41 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (10.95 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (10.95 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.3802 mL | 21.9010 mL | 43.8020 mL | |
| 5 mM | 0.8760 mL | 4.3802 mL | 8.7604 mL | |
| 10 mM | 0.4380 mL | 2.1901 mL | 4.3802 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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