| Size | Price | Stock | Qty |
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| 10mg |
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| 50mg |
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| 100mg |
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| ln Vitro |
In differentiated PC12 cells, S-allyl-L-cysteine was reported to inhibit cell death caused by amyloid(A) and tunicamycin. In a concentration-dependent manner, simultaneous administration of 1 μM S-allyl-L-cysteine prevented Aβ25-35- and Aβ1-40-induced cell death while maintaining nearly full neuronal integrity. The levels of ROS generated by Aβ were dramatically decreased by applying S-allyl-L-cysteine simultaneously. S-allyl-L-cysteine's TEAC value was less than that of oxidized GSH, and there was no discernible antioxidant action. After a 24-hour administration of S-allyl-L-cysteine to neurons, there was no discernible change in intracellular GSH levels. Moreover, the upregulation of caspase-12 protein expression can be inhibited by concurrently adding 1 μM S-allyl-L-cysteine [1]. Brightfield microscopy revealed that S-allyl-L-cysteine, at concentrations as high as 1.0 mM, had no deleterious impact on the morphology of myoblasts and myotubes in culture. Intracellular CK activity was significantly reduced by TNF treatment, and the release of CK into the culture medium was decreased in TNF-treated myotubes that had first been pretreated with S-allyl-L-cysteine. The S-allyl-L-cysteine + TNF group's levels of the active form of the enzyme were lowered by the S-allyl-L-cysteine pretreatment. Comparable findings were noted for the amounts of caspase-3 mRNA. These findings suggest that S-allyl-L-cysteine inhibits the transcription and protein production of caspase-3, which in turn affects apoptotic signaling [2].
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| References |
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| Additional Infomation |
S-allylcysteine is an S-hydrocarbyl-L-cysteine that is L-cysteine in which the hydrogen attached to the sulphur is replaced by a prop-2-enyl group. It commonly occurs in garlic and has been found to exhibit antineoplastic activity. It has a role as a metabolite and an antineoplastic agent. It is a tautomer of a S-allylcysteine zwitterion.
S-allyl-L-cysteine has been reported in Allium sativum, Euglena gracilis, and other organisms with data available. See also: Garlic (part of). |
| Molecular Formula |
C6H11NO2S
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|---|---|
| Molecular Weight |
161.22204
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| Exact Mass |
161.051
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| CAS # |
21593-77-1
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| PubChem CID |
9793905
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| Appearance |
White to off-white solid powder
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| Density |
1.191
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| Boiling Point |
300 ºC
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| Melting Point |
235-236 ºC
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| Flash Point |
135 ºC
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| Vapour Pressure |
0.0±1.3 mmHg at 25°C
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| Index of Refraction |
1.543
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| LogP |
1.31
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
10
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| Complexity |
127
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| Defined Atom Stereocenter Count |
1
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| SMILES |
C=CCSC[C@@H](C(=O)O)N
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| InChi Key |
ZFAHNWWNDFHPOH-YFKPBYRVSA-N
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| InChi Code |
InChI=1S/C6H11NO2S/c1-2-3-10-4-5(7)6(8)9/h2,5H,1,3-4,7H2,(H,8,9)/t5-/m0/s1
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| Chemical Name |
(2R)-2-amino-3-prop-2-enylsulfanylpropanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~16.67 mg/mL (~103.40 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (310.14 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.2027 mL | 31.0135 mL | 62.0270 mL | |
| 5 mM | 1.2405 mL | 6.2027 mL | 12.4054 mL | |
| 10 mM | 0.6203 mL | 3.1014 mL | 6.2027 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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