Size | Price | Stock | Qty |
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5mg |
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10mg |
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50mg |
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100mg |
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Other Sizes |
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ln Vitro |
There are two enantiomers of natural racemic gossypol: (-)-gossypol and (S)-gossypol ((+)-gossypol). The binding affinities of (+)- and (-)-gossypol to Bcl-2 or Bcl-xL are identical. It is more effective for causing apoptosis and suppressing cell proliferation to use (-)-gossypol rather than (+)-gossypol. In a 6-day MTT experiment, the racemic form of gossypol and each enantiomer were evaluated against UM-SCC-6 and UM-SCC-14A. (-)-gossypol showed a higher degree of growth inhibition in comparison to (±)-gossypol than (+)-gossypol in both examined cell lines (P<0.001). The growth inhibitory impact of (±)-gossypol is moderate, however it is only noticeable at higher dosages (10 μM, P<0.0001) [1].
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References |
[1]. Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63
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Molecular Formula |
C32H34O10
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Molecular Weight |
578.606370449066
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CAS # |
1189561-66-7
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Related CAS # |
(R)-(-)-Gossypol acetic acid;866541-93-7;Gossypol (acetic acid);12542-36-8;(R)-(-)-Gossypol;90141-22-3
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
OC1C2=C(C=O)C(=C(C(C(C)C)=C2C=C(C)C=1C1=C(C2=C(C=O)C(=C(C(C(C)C)=C2C=C1C)O)O)O)O)O.OC(C)=O
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~50 mg/mL (~86.41 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (4.32 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.7283 mL | 8.6414 mL | 17.2828 mL | |
5 mM | 0.3457 mL | 1.7283 mL | 3.4566 mL | |
10 mM | 0.1728 mL | 0.8641 mL | 1.7283 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.