| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
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| ln Vitro |
Sarafloxacin (hydrochloride) is an antibiotic classified as a fluoroquinolone that is approved to treat illnesses in poultry. The results of the test indicated that the mineralization rates of 14CO2 in soil, silt soil, and sandy soil were, respectively, 0.58%, 0.49%, and 0.57% after the application of Sarafloxacin hydrochloride treatment [1]. Sarafloxacin hydrochloride's amount of inhibition on test cells varied. Sarafloxacin hydrochloride concentrations in broth seemed to affect E. Coli isolates five times less than in the simulated culture model, indicating that sarafloxacin might be partially inaccessible because of the model's consumption of organic matter [2].
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| ln Vivo |
Sarafloxacin hydrochloride (hydrochloride) was shown to be successful in treating E. coli in each of the three field experiments. added to fish feed for five days at a dose of 10 or 12.5 mg/kg of ictaluri-infected solutions. In Trial 1, Trial 2, and Trial 3, the nongroup drug mean was 43%, 11%, and 59%, respectively. For the drug group using sarafloxacin hydrochloride, the equivalent averages were 68%, 48%, and 73%. In every trial, sarafloxacin hydrochloride was used as an antibiotic, and it significantly (P 0.05) increased survival [3].
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| References |
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| Additional Infomation |
Sarafloxacin hydrochloride is a member of quinolines.
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| Molecular Formula |
C20H18CLF2N3O3
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|---|---|
| Molecular Weight |
421.82
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| Exact Mass |
421.1
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| CAS # |
91296-87-6
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| Related CAS # |
Sarafloxacin;98105-99-8;Sarafloxacin-d8 hydrochloride trihydrate
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| PubChem CID |
56207
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| Appearance |
White to off-white solid powder
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| Density |
1.4±0.1 g/cm3
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| Boiling Point |
621.4±55.0 °C at 760 mmHg
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| Melting Point |
275ºC
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| Flash Point |
329.6±31.5 °C
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| Vapour Pressure |
0.0±1.9 mmHg at 25°C
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| Index of Refraction |
1.633
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| LogP |
2.09
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
29
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| Complexity |
645
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
KNWODGJQLCISLC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C20H17F2N3O3.ClH/c21-12-1-3-13(4-2-12)25-11-15(20(27)28)19(26)14-9-16(22)18(10-17(14)25)24-7-5-23-6-8-24;/h1-4,9-11,23H,5-8H2,(H,27,28);1H
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| Chemical Name |
6-fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrochloride
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| Synonyms |
A-56620; Sarafloxacin Hydrochloride; Sarafloxacin HCl
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~8.33 mg/mL (~19.75 mM)
H2O : ~1 mg/mL (~2.37 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.83 mg/mL (1.97 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 8.3 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.83 mg/mL (1.97 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 8.3 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 0.83 mg/mL (1.97 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3707 mL | 11.8534 mL | 23.7068 mL | |
| 5 mM | 0.4741 mL | 2.3707 mL | 4.7414 mL | |
| 10 mM | 0.2371 mL | 1.1853 mL | 2.3707 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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