| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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| ln Vitro |
In whole blood, SC-57461A suppresses the synthesis of LTB4 induced by ionophores with IC50 values of 49, 166, and 466 nM for human, mouse, and topovirus, respectively [1]. The LTA4 fine-tuned enzyme (IC50=2.5 nM) and entire cells (IC50=49 nM) are both effectively inhibited by SC-57461A [2].
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| ln Vivo |
SC-57461A also showed excellent effects in in vitro mouse experiments, inhibiting the production of LTB4 with ED50=0.2 mg/kg and ED90=1 mg/kg. SC-57461A also inhibits LTB4 production in the peritoneal model with ED50=1 mg/kg[2]. SC-57461A is a potent, selective, competitive inhibitor of the LTA4 disinfecting enzyme with excellent activity in whole animals. SC-57461A in mice and mice
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| Animal Protocol |
Animal/Disease Models: Fasted CD rat [3]
Doses: 0.01, 0.1, 1 and 10 mg/kg Route of Administration: Oral Experimental Results: ED50 value at 1.0 is 0.2 mg/kg . h and 0.8 mg/kg at 3.0 h. A single dose of 10 mg/kg prevented 79%, 67% and 44% of LTB4 production at 6 hrs (hrs (hours)), 18 hrs (hrs (hours)) and 24 hrs (hrs (hours)), respectively. |
| References |
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| Molecular Formula |
C20H25NO3
|
|---|---|
| Molecular Weight |
327.42
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| Exact Mass |
363.16
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| CAS # |
423169-68-0
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| PubChem CID |
9820433
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| Appearance |
White to off-white solid powder
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| Density |
1.115g/cm3
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| Boiling Point |
499.7ºC at 760 mmHg
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| Flash Point |
256.01ºC
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| Index of Refraction |
1.562
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| LogP |
4.254
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
10
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| Heavy Atom Count |
25
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| Complexity |
347
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| Defined Atom Stereocenter Count |
0
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| Synonyms |
SC57461; SC-57461; SC 57461
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~687.04 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (5.72 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (5.72 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (5.72 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0542 mL | 15.2709 mL | 30.5418 mL | |
| 5 mM | 0.6108 mL | 3.0542 mL | 6.1084 mL | |
| 10 mM | 0.3054 mL | 1.5271 mL | 3.0542 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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