Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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Other Sizes |
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Purity: ≥98%
SCH 23390 hydrochloride is a novel and potent dopamine receptor antagonist with Ki values of 0.2 and 0.3 nM for the D1 and D5. SCH 23390 is additionally an agonist at in vitro 5-HT1C and 5-HT2C receptors (Ki values are 6.3 nM and 9.3 nM respectively).
ln Vitro |
SCH-23390 (1 μM) treatmentoverrode the inhibitory effect of isosibiricin on BV-2 cells' LPS-induced NLRP3 expression, caspase-1, and IL-1β cleavage. SCH-23390 can undo the NLRP3/caspase-1 inflammasome pathway's inhibition caused by isosibiricin.
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ln Vivo |
SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants. SCH-23390 has also been used in research on other neurological conditions like psychosis and Parkinson's disease where there is evidence of a dopaminergic connection. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D1 receptors in rodents, nonhuman primates, and humans[1]. After giving a rat 0.3 mg/kg i.p., SCH-23390 is a very short-acting drug with an elimination half-life of about 25 min[1].
SCH-23390 increases dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O2 conditions[5].
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References |
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Molecular Formula |
C17H19CL2NO
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Molecular Weight |
324.24486
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Exact Mass |
323.08
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Elemental Analysis |
C, 62.97; H, 5.91; Cl, 21.87; N, 4.32; O, 4.93
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CAS # |
125941-87-9
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Related CAS # |
SCH-23390 maleate; 87134-87-0; 87075-17-0
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Appearance |
Solid powder
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SMILES |
CN1CCC2=CC(=C(C=C2[C@H](C1)C3=CC=CC=C3)O)Cl.Cl
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InChi Key |
OYCAEWMSOPMASE-XFULWGLBSA-N
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InChi Code |
InChI=1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
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Chemical Name |
(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol;hydrochloride
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Synonyms |
SCH 23390 HCl; SCH-23390; SCH23390
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ≥ 32 mg/mL (~98.69 mM)
H2O : ~28.57 mg/mL (~88.11 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (6.42 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.0841 mL | 15.4207 mL | 30.8414 mL | |
5 mM | 0.6168 mL | 3.0841 mL | 6.1683 mL | |
10 mM | 0.3084 mL | 1.5421 mL | 3.0841 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.