| Size | Price | Stock | Qty |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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| ln Vitro |
Schisandrin C (25-100 μM; 48 hours) down-regulates expression levels of Bcl-2, Bcl-xL and a concomitant degradation of poly(ADP-ribose) polymerase (PARP). Additionally, in U937 cells, it activates caspase-3 and -9[2].
Schisandrin C (25-100 μM; 48 hours) induces apoptosis in a dose-dependent manner. Additionally, U937 cells exhibit increased genomic DNA fragmentation[1]. Schisandrin C (25-100 μM; 72 hours) induces G1 arrest, down-regulates the expression of cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4, and E2Fs, as well as inhibiting pRB and enhancing the Cdk inhibitor p21(WAF1/CIP1)[1]. |
|---|---|
| ln Vivo |
Schisandrin C (lateral ventricle injection (i.c.v. ); 15–150 g/kg; 5 days) lessens Aβ1-42-induced memory deficits in the Y-maze test. The hippocampus' neurons in the SCH-C (15 μg/kg)-treated group recovered to normal levels, and the SCH-C group (150 μg/kg) had a minimally neuroprotective effect on the Aβ1–42-induced group. In the brains of the Aβ1–42-induced amnesic mice, SCH-C (15 μg/kg) simultaneously reduces ChEtotal levels while increasing SOD and GSHPx activities and ratios[3].
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| Animal Protocol |
Aβ1-42-induced Alzheimer’s disease mice[3]
15-150 μg/kg Lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days |
| References |
|
| Molecular Formula |
C22H24O6
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|---|---|
| Molecular Weight |
384.42
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| Exact Mass |
384.1573
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| Elemental Analysis |
C, 68.74; H, 6.29; O, 24.97
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| CAS # |
61301-33-5
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| Related CAS # |
Schisandrin;7432-28-2
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| Appearance |
Solid powder
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| SMILES |
CC1CC2=CC3=C(C(=C2C4=C(C5=C(C=C4CC1C)OCO5)OC)OC)OCO3
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| InChi Key |
HTBWBWWADZJXID-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C22H24O6/c1-11-5-13-7-15-19(27-9-25-15)21(23-3)17(13)18-14(6-12(11)2)8-16-20(22(18)24-4)28-10-26-16/h7-8,11-12H,5-6,9-10H2,1-4H3
|
| Chemical Name |
3,22-dimethoxy-12,13-dimethyl-5,7,18,20-tetraoxapentacyclo[13.7.0.02,10.04,8.017,21]docosa-1(22),2,4(8),9,15,17(21)-hexaene
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| Synonyms |
Schizandrin-C; Schizandrin C
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| HS Tariff Code |
2934.99.03.00
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 8.3~77 mg/mL (21.7~200.3 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.83 mg/mL (2.16 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 8.3 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.83 mg/mL (2.16 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 8.3 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6013 mL | 13.0066 mL | 26.0132 mL | |
| 5 mM | 0.5203 mL | 2.6013 mL | 5.2026 mL | |
| 10 mM | 0.2601 mL | 1.3007 mL | 2.6013 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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