Size | Price | Stock | Qty |
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2mg |
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5mg |
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10mg |
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25mg |
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50mg |
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Other Sizes |
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Seractide,also known as ACTH (1-39) , is a novel and potent endogenous melanocortin receptor 2 (MC2) agonist (EC50 = 57 pM).
ln Vitro |
In humans, the melanocortin family member adrenocorticotropic hormone (ACTH) (1-39) increases the production of CS first, but it also does so in the immune system and central nervous system (CNS). Neuronal platforms are externally protected by ACTH 1-39 against various cellular, excitotoxic, and hazard-related insults [1]. Astrocytes (AS) cultures that were left untreated and AS cultures that were exposed to 200 nM ACTH 1-39 for 24 hours, rinsed to remove ACTH 1-39, and then in DMEM Dye for an additional 24 hours were used to generate conditioned medium (CM). In the first trials, 2% newborn calf serum (NCS) or AS CM (made in DMEM with clear serum) in the OL-formulated media did not result in oligodendrocyte (OL) viability. distinction. When OL was introduced at 1% to 4% MG (MG) CM, most cases of OL introduction showed similar results on OL viability after 24 hours. In the tests that followed, OL in predefined cells with 2% NCS served as the control in every trial [2].
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References |
[1]. Lisak RP, et al. Melanocortin receptor agonist ACTH 1-39 protects rat forebrain neurons from apoptotic, excitotoxic and inflammation-related damage. Exp Neurol. 2015 Nov;273:161-7.
[2]. Lisak RP, et al. The melanocortin ACTH 1-39 promotes protection of oligodendrocytes by astroglia. J Neurol Sci. 2016 Mar 15;362:21-6 |
Molecular Formula |
C207H308N56O58S
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Molecular Weight |
4541.07
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CAS # |
12279-41-3
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Related CAS # |
Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA);Adrenocorticotropic Hormone (ACTH) (1-39), human acetate
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
N1(CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1C=CC=CC=1)C(O)=O)CC(N)=O)C(=O)[C@H](CC1C=CC(=CC=1)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(CNC(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(CNC(=O)[C@H](CC1C2C=CC=CC=2NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC1C=CC(=CC=1)O)NC(=O)[C@H](CO)N)=O)=O
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Synonyms |
ACTH (1-39) Seractide
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ≥ 50 mg/mL (~11.01 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (22.02 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 0.2202 mL | 1.1011 mL | 2.2021 mL | |
5 mM | 0.0440 mL | 0.2202 mL | 0.4404 mL | |
10 mM | 0.0220 mL | 0.1101 mL | 0.2202 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.