Size | Price | Stock | Qty |
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10mg |
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25mg |
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50mg |
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100mg |
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Other Sizes |
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SHA 68 (SHA-68, SHA68) is a novel, highly potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. It has been observed that SHA 68 reduces neuralgia activity and blood-brain barrier (BBB) penetration.
Targets |
Asn107 ( IC50 = 22 nM ); Ile107 ( IC50 = 23.8 nM )
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ln Vivo |
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Animal Protocol |
Male C57BL/6 mice age 8-12 weeks
5 and 50 mg/kg i.p. |
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References |
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Molecular Formula |
C26H24FN3O3
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Molecular Weight |
445.485469818115
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Exact Mass |
445.18
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Elemental Analysis |
C, 70.10; H, 5.43; F, 4.26; N, 9.43; O, 10.77
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CAS # |
847553-89-3
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Appearance |
Solid powder
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SMILES |
C1CN2C(CN1C(=O)NCC3=CC=C(C=C3)F)C(OC2=O)(C4=CC=CC=C4)C5=CC=CC=C5
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InChi Key |
SFRQIPRTNYHJHP-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C26H24FN3O3/c27-22-13-11-19(12-14-22)17-28-24(31)29-15-16-30-23(18-29)26(33-25(30)32,20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,23H,15-18H2,(H,28,31)
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Chemical Name |
N-[(4-fluorophenyl)methyl]-3-oxo-1,1-diphenyl-5,6,8,8a-tetrahydro-[1,3]oxazolo[3,4-a]pyrazine-7-carboxamide
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Synonyms |
SHA68; SHA-68; SHA 68
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: ~250 mg/mL (~561.2 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.67 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.67 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.2447 mL | 11.2236 mL | 22.4472 mL | |
5 mM | 0.4489 mL | 2.2447 mL | 4.4894 mL | |
10 mM | 0.2245 mL | 1.1224 mL | 2.2447 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Pharmacological activity of SHA 66 (A, B) and SHA 68 (C, D) at NPSR Asn107 (NPSR-N107) and NPSR Ile107 (NPSR-I107). J Pharmacol Exp Ther . 2008 Jun;325(3):893-901. td> |
Pharmacokinetic analysis of SHA 68 in mice. J Pharmacol Exp Ther . 2008 Jun;325(3):893-901. td> |