| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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SIRT7 inhibitor 97491 is a novel SIRT7 inhibitor with antitumor activity. It reduces the deacetylase activity of SIRT7 with an IC50 of 325 nM.
| Targets |
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|---|---|---|
| ln Vitro |
The SIRT7 inhibitor 97491 (1–10 μM) inhibits MES-SA cell growth without harming HEK293 cells [1].
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| ln Vivo |
Tumor growth in xenograft mice is inhibited by SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally; for 3 weeks, excluding weekends) [1].
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| Cell Assay |
Cell Proliferation Assay[1]
Cell Types: Human uterine sarcoma MES-SA cells Tested Concentrations: 1, 5, 10 μM Incubation Duration: 72 hrs (hours) Experimental Results: Led to more than 50% decrease in cell proliferation at concentrations of 5 and 10 μM. Cell Cytotoxicity Assay[1] Cell Types: Human embryonic kidney cell line HEK293 cells Tested Concentrations: 1, 5, 10 μM Incubation Duration: 24 hrs (hours) Experimental Results: HEK293 cells were almost unaffected. |
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| Animal Protocol |
Animal/Disease Models: Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells[1]
Doses: 2 mg/kg Route of Administration: Intraperitoneally injected; for 3 weeks, except on weekends. Experimental Results: Inhibited cancer growth in vivo. |
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| References |
| Molecular Formula |
C15H12CLN3O
|
|---|---|
| Molecular Weight |
285.728281974792
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| Exact Mass |
285.066
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| CAS # |
1807758-81-1
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| PubChem CID |
146018038
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| Appearance |
Off-white to light yellow solid powder
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| LogP |
3.8
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
20
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| Complexity |
310
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| Defined Atom Stereocenter Count |
0
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| SMILES |
ClC1C=CC(=CC=1)C1=CN=C(NC2C=CC=C(C=2)N)O1
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| InChi Key |
RMRVZWMKRCLSFX-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C15H12ClN3O/c16-11-6-4-10(5-7-11)14-9-18-15(20-14)19-13-3-1-2-12(17)8-13/h1-9H,17H2,(H,18,19)
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| Chemical Name |
3-N-[5-(4-chlorophenyl)-1,3-oxazol-2-yl]benzene-1,3-diamine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~500 mg/mL (~1749.90 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 4.17 mg/mL (14.59 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 41.7 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. Solubility in Formulation 2: 10 mg/mL (35.00 mM) in 50% PEG300 50% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4998 mL | 17.4990 mL | 34.9981 mL | |
| 5 mM | 0.7000 mL | 3.4998 mL | 6.9996 mL | |
| 10 mM | 0.3500 mL | 1.7499 mL | 3.4998 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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