| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
|
||
| 10mg |
|
||
| 25mg |
|
||
| 50mg |
|
||
| 100mg |
|
||
| 250mg |
|
||
| 500mg |
|
||
| Other Sizes |
|
Purity: ≥98%
SKF-82958 HBr, the hydrobromide salt of SKF-81297, is a novel, potent and selective dopamine D1/D5 receptor full agonist which stimulates motor behaviour of MPTP-lesioned monkeys.
| ln Vivo |
SKF-82958 ((±)-SKF 82958) (0.003-0.1 mg/kg; i.p.) causes a dose-dependent increase in response on the SKF-82958 appropriate lever. Full substitution happens after the training dose of 0.03 mg/kg of SKF-82958 has been administered. The response rate to SKF-82958 is likewise significantly decreased when the dose is increased[2].
SKF-82958 (0.5-2.0 mg/kg; i.p) significantly inhibits pilocarpine-induced jaw movements[3]. |
|---|---|
| Animal Protocol |
Male Sprague-Dawley rats
0.5-2.0 mg/kg I.p |
| References |
|
| Molecular Formula |
C19H20CLNO2
|
|---|---|
| Molecular Weight |
410.73
|
| Exact Mass |
409.044
|
| Elemental Analysis |
C, 55.56; H, 5.15; Br, 19.45; Cl, 8.63; N, 3.41; O, 7.79
|
| CAS # |
74115-01-8
|
| Related CAS # |
SKF-82958; 80751-65-1
|
| PubChem CID |
9909521
|
| Appearance |
Solid powder
|
| LogP |
4.823
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
24
|
| Complexity |
399
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
OC1=C(O)C=C2C(C3=CC=CC=C3)CN(CC=C)CCC2=C1Cl.[H]Br
|
| InChi Key |
WLXGFAVTAAQOFH-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H
|
| Chemical Name |
9-chloro-5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol;hydrobromide
|
| Synonyms |
(±)-SKF 82958 hydrobromide; Chloro-APB hydrobromide; SKF-81297 HBr; SKF-81297; SKF 81297; SKF81297; (±)-SKF 82958; Chloro-AP
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~243.47 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.09 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (6.09 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (6.09 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4347 mL | 12.1734 mL | 24.3469 mL | |
| 5 mM | 0.4869 mL | 2.4347 mL | 4.8694 mL | |
| 10 mM | 0.2435 mL | 1.2173 mL | 2.4347 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
COA