| Size | Price | Stock | Qty |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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SNC80 (SNC-80; SNC 80) is a novel, potent, selective, systemically active non-peptide δ(delta)-opioid agonist with potential antinociceptiveand pro-convulsant activities in vivo. It demonstrates a selectivity over μ-opioid receptors of over 2000 times.
| Targets |
δ-opioid receptor ( IC50 = 2.73 nM ); μ-opioid receptor ( IC50 = 5457 nM ); δ-opioid receptor) ( Ki = 1.78 nM ); μ-opioid receptor ( IC50 = 881.5 nM ); κ-opioid receptor ( IC50 = 441.8 nM )
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| ln Vitro |
SNC80 selectively activates the μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows noticeably more activity in cells that coexpress μ- and δ-opioid receptors than in those that either express δ-opioid receptors alone or in combination with ν- and κ-opioid receptors[4].
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| ln Vivo |
SNC80 (10 mg/kg; intraperitoneal injection; once; C57BL6/J mice) treatment significantly reduced the allodynia brought on by excessive sumatriptan usage[1].
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| Animal Protocol |
Male and female C57BL6/J mice (20-30g) injected with Sumatriptan
10 mg/kg Intraperitoneal injection; once |
| References | |
| Additional Infomation |
4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enyl-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide is a diarylmethane.
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| Molecular Formula |
C28H39N3O2
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|---|---|
| Molecular Weight |
449.64
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| Exact Mass |
449.304
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| Elemental Analysis |
C, 74.80; H, 8.74; N, 9.35; O, 7.12
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| CAS # |
156727-74-1
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| PubChem CID |
123924
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| Appearance |
Off-white to light yellow solid powder
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
564.8±50.0 °C at 760 mmHg
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| Melting Point |
122-123ºC
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| Flash Point |
295.4±30.1 °C
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| Vapour Pressure |
0.0±1.5 mmHg at 25°C
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| Index of Refraction |
1.545
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| LogP |
3.37
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
9
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| Heavy Atom Count |
33
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| Complexity |
614
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| Defined Atom Stereocenter Count |
3
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| SMILES |
C=CCN1C[C@H](C)N(C[C@H]1C)[C@H](C2=CC=C(C=C2)C(=O)N(CC)CC)C3=CC(=CC=C3)OC
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| InChi Key |
KQWVAUSXZDRQPZ-UMTXDNHDSA-N
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| InChi Code |
InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
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| Chemical Name |
4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide
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| Synonyms |
SNC80; SNC-80; SNC80
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~33.33 mg/mL (~74.1 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 3.33 mg/mL (7.41 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 33.3 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 3.33 mg/mL (7.41 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 33.3 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 3.33 mg/mL (7.41 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2240 mL | 11.1200 mL | 22.2400 mL | |
| 5 mM | 0.4448 mL | 2.2240 mL | 4.4480 mL | |
| 10 mM | 0.2224 mL | 1.1120 mL | 2.2240 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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