| Size | Price | Stock | Qty |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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SR-18662 is an optimized anticancel agent based on ML264. Treatment with SR-18662 has been shown to significantly slow the growth and division of colorectal cancer cells. The effect of SR-18662 at the same dose was greater than that of ML264 in terms of significantly inhibiting the growth of mice xenografts.
| Targets |
KLF5 (IC50 = 4.4 nM)
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|---|---|
| ln Vitro |
SR18662 (0-10 μM; 24-72 hours) significantly lessens CRC cell growth and proliferation when compared to ML264 , the vehicle control. It demonstrates improved effectiveness in lowering the viability of various CRC cell lines[1].
SR18662 (10 μM; 24-72 hours) shows a significant increase in the quantity of apoptotic cells in the DLD-1 and HCT116 cells in both the early and late states[1]. SR18662 (1 μM; 72 hours) reduces the expression of cyclins (cyclins E, A2, and B1), as well as elements of the MAPK (p-Erk) and WNT signaling pathways (p-GSK3 β) in cellular expression[1]. |
| ln Vivo |
SR18662 (intraperitoneal injection; 5-10 mg/kg; daily or twice daily; 5 days injection, days break, and 5 days) significantly slows the growth of tumors in a mouse xenograft model[1].
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| Animal Protocol |
Nude mice with DLD-1 cells[1]
5 mg/kg; 10 mg/kg; 25 mg/kg Intraperitoneal injection; 5mg/kg daily, 5mg/kg twice a day,10 mg/kg daily, 10 mg/kg twice per day, 25mg/kg daily, and 25 mg/kg twice per day; 5 days of injections, 2 days break, and 5 days of injections |
| References |
| Molecular Formula |
C16H19CL2N3O4S
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|---|---|
| Molecular Weight |
420.3108
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| Exact Mass |
419.047
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| Elemental Analysis |
C, 45.72; H, 4.56; Cl, 16.87; N, 10.00; O, 15.23; S, 7.63
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| CAS # |
2505001-62-5
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| Related CAS # |
2505001-62-5
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| PubChem CID |
146674222
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| Appearance |
White to off-white solid powder
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| LogP |
1.5
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
26
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| Complexity |
642
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CS(=O)(=O)N1CCN(CC1)C(=O)CNC(=O)/C=C/C2=CC(=C(C=C2)Cl)Cl
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| InChi Key |
WUJBXFXHDUVSFM-HWKANZROSA-N
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| InChi Code |
InChI=1S/C16H19Cl2N3O4S/c1-26(24,25)21-8-6-20(7-9-21)16(23)11-19-15(22)5-3-12-2-4-13(17)14(18)10-12/h2-5,10H,6-9,11H2,1H3,(H,19,22)/b5-3+
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| Chemical Name |
(E)-3-(3,4-dichlorophenyl)-N-[2-(4-methylsulfonylpiperazin-1-yl)-2-oxoethyl]prop-2-enamide
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| Synonyms |
SR-18662; SR 18662; SR18662
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 84~125 mg/mL (199.9~297.4 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.08 mg/mL (4.95 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.95 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3792 mL | 11.8960 mL | 23.7920 mL | |
| 5 mM | 0.4758 mL | 2.3792 mL | 4.7584 mL | |
| 10 mM | 0.2379 mL | 1.1896 mL | 2.3792 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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