| Size | Price | Stock | Qty |
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| 2mg |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
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| ln Vitro |
The stimulation of [35S]GTPγS caused by GABA alone was greatly amplified (about 170% above basal levels) by 25 µM SSD114 hydrochloride in the presence of 10 µM GABA. The GABA concentration-response curve shifted leftward with the addition of 15 and 30 µM SSD114 hydrochloride, and the maximum GABA stimulation at the highest dose increased slightly. The EC50 of GABA was reduced by two and 2.5 times, respectively, in the presence of 15 µM and 30 µM SSD114 hydrochloride; however, the maximum stimulation (Emax) was only increased at 30 µM concentration, reaching a value of 161±5.09% of the basal value [1].
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|---|---|
| ln Vivo |
Pretreatment with SSD114 hydrochloride has been shown to decrease the incidence of loss of righting reflex (LORR) [F(5,30)=4.55, P<0.005]. A post hoc analysis revealed a significant difference in the incidence of LORR between the mice treated with vehicle and the group pretreated with SSD114 hydrochloride at a level of at least 10 mg/kg. Longer LORR durations can be achieved by pretreating with SSD114 hydrochloride [F(5,30)=4.81, P<0.005]. The duration of LORR in the mouse groups pretreated with 10 and 100 mg/kg SSD114 hydrochloride was shown to be considerably longer than in the mice treated with vehicle, according to post hoc analysis [1].
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| References |
| Molecular Formula |
C18H21CLF3N3O
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|---|---|
| Molecular Weight |
387.827053785324
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| Exact Mass |
387.132
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| Elemental Analysis |
C, 55.75; H, 5.46; Cl, 9.14; F, 14.70; N, 10.83; O, 4.13
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| CAS # |
2319790-02-6
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| Related CAS # |
2319790-02-6
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| PubChem CID |
131839612
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| Appearance |
White to off-white solid powder
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
26
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| Complexity |
407
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| Defined Atom Stereocenter Count |
0
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| SMILES |
Cl.FC(C1C=CC(=CC=1)C1=CC(=NC(=N1)NC1CCCCC1)OC)(F)F
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| InChi Key |
YXQSTPASDICGCA-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C18H20F3N3O.ClH/c1-25-16-11-15(12-7-9-13(10-8-12)18(19,20)21)23-17(24-16)22-14-5-3-2-4-6-14;/h7-11,14H,2-6H2,1H3,(H,22,23,24);1H
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| Chemical Name |
C18H21ClF3N3OMolecular Weight
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| Synonyms |
SSD114 HCl SSD114 SSD-114 SSD 114 SSD114 hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~130 mg/mL (~335.20 mM)
H2O : ~2 mg/mL (~5.16 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 3.25 mg/mL (8.38 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 32.5 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 3.25 mg/mL (8.38 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 32.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 3.25 mg/mL (8.38 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5784 mL | 12.8922 mL | 25.7845 mL | |
| 5 mM | 0.5157 mL | 2.5784 mL | 5.1569 mL | |
| 10 mM | 0.2578 mL | 1.2892 mL | 2.5784 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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