SSD114 HCl

Alias: SSD114 HCl SSD114 SSD-114 SSD 114 SSD114 hydrochloride
Cat No.:V0049 Purity: ≥98%
SSD114 HCl is a novel positive allosteric modulator (PAM) of GABAB receptors.
SSD114 HCl Chemical Structure CAS No.: 2319790-02-6
Product category: GABA Receptor
This product is for research use only, not for human use. We do not sell to patients.
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Product Description
SSD114 HCl is a novel positive allosteric modulator (PAM) of GABAB receptors.
Biological Activity I Assay Protocols (From Reference)
ln Vitro
The stimulation of [35S]GTPγS caused by GABA alone was greatly amplified (about 170% above basal levels) by 25 µM SSD114 hydrochloride in the presence of 10 µM GABA. The GABA concentration-response curve shifted leftward with the addition of 15 and 30 µM SSD114 hydrochloride, and the maximum GABA stimulation at the highest dose increased slightly. The EC50 of GABA was reduced by two and 2.5 times, respectively, in the presence of 15 µM and 30 µM SSD114 hydrochloride; however, the maximum stimulation (Emax) was only increased at 30 µM concentration, reaching a value of 161±5.09% of the basal value [1].
ln Vivo
Pretreatment with SSD114 hydrochloride has been shown to decrease the incidence of loss of righting reflex (LORR) [F(5,30)=4.55, P<0.005]. A post hoc analysis revealed a significant difference in the incidence of LORR between the mice treated with vehicle and the group pretreated with SSD114 hydrochloride at a level of at least 10 mg/kg. Longer LORR durations can be achieved by pretreating with SSD114 hydrochloride [F(5,30)=4.81, P<0.005]. The duration of LORR in the mouse groups pretreated with 10 and 100 mg/kg SSD114 hydrochloride was shown to be considerably longer than in the mice treated with vehicle, according to post hoc analysis [1].
References
[1]. Porcu A, et al. In vitro and in vivo pharmacological characterization of SSD114, a novel GABAB positive allosteric modulator. Eur J Pharmacol. 2016 Nov 15;791:115-123
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C18H21CLF3N3O
Molecular Weight
387.827053785324
CAS #
2319790-02-6
SMILES
Cl.FC(C1C=CC(=CC=1)C1=CC(=NC(=N1)NC1CCCCC1)OC)(F)F
Chemical Name
C18H21ClF3N3OMolecular Weight
Synonyms
SSD114 HCl SSD114 SSD-114 SSD 114 SSD114 hydrochloride
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO : ~130 mg/mL (~335.20 mM)
H2O : ~2 mg/mL (~5.16 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.5784 mL 12.8922 mL 25.7845 mL
5 mM 0.5157 mL 2.5784 mL 5.1569 mL
10 mM 0.2578 mL 1.2892 mL 2.5784 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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