| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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ST-193 (ST193) is a novel and potent arenavirus inhibitor with a broad-spectrum of antiviral activity. It is active against Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.
| ln Vitro |
At a 1.6 nM IC50, ST-193 suppresses LASV pseudotypes. At concentrations of up to 10 μM, ST-193 shows no antiviral activity against pseudotypes incorporating either the GP from the LASV-related arenavirus lymphocytic choriomeningitis virus or the unrelated G protein from vesicular stomatitis virus. However, it inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four common associated with hemorrhagic fever (IC50s for Junín, Machupo, Guanarito, and Sabiá were in the 0.2 to 12 nM range).
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| ln Vivo |
When given daily as an intraperitoneal injection of either 25 or 100 mg/kg/day for 14 days, ST-193 is proven to be well tolerated. Animals treated with ST-193 show improved survival rates and less illness symptoms than the ribavirin or vehicle groups. All groups see an increase in body temperature by day 9, but most ST-193-treated animals' body temperatures return to normal by day 19 after infection. Comparing ST-193-treated controls to vehicle-treated ones, there is a 2- to 3-log decrease in viremia. In the ST-193-treated guinea pig group, the overall survival rate is 62.5% (10/16), while it is 0% in the ribavirin (0/8) and vehicle (0/7) groups[3].
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| References |
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| Molecular Formula |
C24H25N3O
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|---|---|
| Molecular Weight |
371.4748
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| Exact Mass |
371.199
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| CAS # |
489416-12-8
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| Related CAS # |
ST-193 hydrochloride;2320274-72-2
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| PubChem CID |
3697969
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| Appearance |
Off-white to pink solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
562.5±60.0 °C at 760 mmHg
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| Flash Point |
294.0±32.9 °C
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| Vapour Pressure |
0.0±1.5 mmHg at 25°C
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| Index of Refraction |
1.609
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| LogP |
5.8
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
28
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| Complexity |
469
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
JPSZEXYTKSIPDW-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C24H25N3O/c1-17(2)19-6-4-18(5-7-19)15-25-20-8-13-24-23(14-20)26-16-27(24)21-9-11-22(28-3)12-10-21/h4-14,16-17,25H,15H2,1-3H3
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| Chemical Name |
1-(4-methoxyphenyl)-N-[(4-propan-2-ylphenyl)methyl]benzimidazol-5-amine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~269.20 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.73 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (6.73 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6920 mL | 13.4600 mL | 26.9201 mL | |
| 5 mM | 0.5384 mL | 2.6920 mL | 5.3840 mL | |
| 10 mM | 0.2692 mL | 1.3460 mL | 2.6920 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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