| Size | Price | Stock | Qty |
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| 5mg |
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| 25mg |
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| 50mg |
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| 100mg |
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Purity: ≥98%
SU-4312, formerly known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 are 0.8 and 19.4 μM respectively). SU4312 selectively and directly inhibits neuronal NOS, providing an unexpected defense against MPP(+)-induced neurotoxicity.
| Targets |
PDGFR; Flk-1
|
|---|---|
| ln Vitro |
It has been demonstrated that receptor tyrosine kinases (RTKs) are crucial mediators of cellular signal transduction in cells. It has been demonstrated that numerous RTKs are oncogene products, indicating their involvement in the transformation process linked to malignancies in humans[1].
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| References | |
| Additional Infomation |
See also: 3-(4-Dimethylamino-benzylidenyl)-2-indolinone (annotation moved to).
|
| Molecular Formula |
C17H16N2O
|
|---|---|
| Molecular Weight |
264.328
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| Exact Mass |
264.126
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| Elemental Analysis |
C, 77.25; H, 6.10; N, 10.60; O, 6.05
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| CAS # |
5812-07-7
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| Related CAS # |
5812-07-7
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| PubChem CID |
6450842
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| Appearance |
Yellow solid powder
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| Density |
1.219g/cm3
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| Boiling Point |
497.1ºC at 760 mmHg
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| Flash Point |
254.5ºC
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| Index of Refraction |
1.683
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| LogP |
3.383
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
20
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| Complexity |
394
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CN(C)C1=CC=C(C=C1)C=C2C3=CC=CC=C3NC2=O
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| InChi Key |
UAKWLVYMKBWHMX-PTNGSMBKSA-N
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| InChi Code |
InChI=1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11-
|
| Chemical Name |
(3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-one
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| Synonyms |
NSC 86429; NSC-86429; NSC86429; SU4312; DMBI; SU-4312; SU 4312
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product is not stable in solution, please use freshly prepared working solution for optimal results. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: ~50 mg/mL (~189.2 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.08 mg/mL (7.87 mM) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7831 mL | 18.9157 mL | 37.8315 mL | |
| 5 mM | 0.7566 mL | 3.7831 mL | 7.5663 mL | |
| 10 mM | 0.3783 mL | 1.8916 mL | 3.7831 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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