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Sulbactam (CP 45899 and Betamaze) is a potent and irreversible β-lactamase inhibitor given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys antibiotic activity. It binds to the enzyme and prevent it to degrade the antibiotic.Sulbactam is able to inhibit the most common forms of β-lactamase but is not able to interact with the AmpC cephalosporinase. Thus, it confers little protection against bacteria such as Pseudomonas aeruginosa, Citrobacter, Enterobacter, and Serratia, which often express this gene.
Targets |
β-lactam
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ln Vitro |
Sulbactam exhibits broad spectrum antibacterial activity against both aerobic and anaerobic Gram-positive and Gram-negative bacteria[3].
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References |
Molecular Formula |
C8H11NO5S
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Molecular Weight |
233.2416
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Exact Mass |
233.04
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Elemental Analysis |
C, 41.20; H, 4.75; N, 6.01; O, 34.30; S, 13.75
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CAS # |
68373-14-8
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Related CAS # |
Sulbactam sodium;69388-84-7
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Appearance |
Solid powder
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SMILES |
CC1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)O)C
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InChi Key |
FKENQMMABCRJMK-RITPCOANSA-N
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InChi Code |
InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1
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Chemical Name |
(2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide
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Synonyms |
CP-45899; CP 45899; CP45899; CP-45,899; CP 45,899; CP45,899; Sulbactam
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : 47~100 mg/mL ( 201.5~428.74 mM )
Water : 20~47 mg/mL(85.75 mM) Ethanol : ~47 mg/mL |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (10.72 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (10.72 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (10.72 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 10% DMSO+40% PEG300+5% Tween-80+45% Saline: ≥ 2.5 mg/mL (10.72 mM) Solubility in Formulation 5: 100 mg/mL (428.74 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 4.2874 mL | 21.4371 mL | 42.8743 mL | |
5 mM | 0.8575 mL | 4.2874 mL | 8.5749 mL | |
10 mM | 0.4287 mL | 2.1437 mL | 4.2874 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
NCT02688322 | COMPLETED | Drug: Sulbactam | Acinetobacter Infections | Sutep Jaruratanasirikul | 2014-09 | Phase 4 |
NCT05535309 | COMPLETED | Drug: cefoperazone sulbactam sodium | Risk Factors | Qianfoshan Hospital | 2021-11-02 | |
NCT01189487 | COMPLETEDWITH RESULTS | Drug: ampicillin sodium/ sulbactam sodium |
Pneumonia, Bacterial | Pfizer | 2010-10 | Phase 3 |
NCT05654090 | ACTIVE, NOT RECRUITING | Drug: cefoperazone sodium and sulbactam sodium |
Infectious Diseases | Yung Shin Pharm. Ind. Co., Ltd. | 2022-08-25 | Phase 4 |
NCT01138852 | COMPLETED | Drug: Ampicillin-sulbactam Drug: Cefuroxime |
Surgical Site Infections | Attikon Hospital | 2004-07 | Phase 4 |