| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| Other Sizes |
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Purity: ≥98%
Sulconazole Nitrate, formerly known as Sulconazole and RS-44872, is an imidazole class of antifungal agent used to treat fungal skin infections.
| ln Vitro |
At doses less than 5 mg/L in vitro, succinazole mononitrate exhibits broad-spectrum antifungal action and can impede the growth of yeasts, dermatophytes, and a variety of filamentous and dimorphic fungi [1]. With a minimum inhibitory concentration (MIC) of less than 12.5 mg/L, succinazole mononitrate has antibacterial activity in vitro against several strains of Staphylococcus aureus, Streptococcus faecalis, and some Gram-positive anaerobic bacteria [1].
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| References | |
| Additional Infomation |
Sulconazole nitrate is an organic nitrate salt, a conazole antifungal drug and an imidazole antifungal drug.
Sulconazole Nitrate is the nitrate salt form of sulconazole, a synthetic imidazole derivative with antifungal property. Sulconazole nitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, sulconazole nitrate seems to interfere with the autolytic degradation of fungal DNA and RNA. See also: Sulconazole (has active moiety). |
| Molecular Formula |
C18H16CL3N3O3S
|
|---|---|
| Molecular Weight |
460.7619
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| Exact Mass |
458.998
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| CAS # |
61318-91-0
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| Related CAS # |
Sulconazole;61318-90-9
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| PubChem CID |
65495
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| Appearance |
White to off-white solid powder
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| Boiling Point |
558.2ºC at 760 mmHg
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| Melting Point |
130.5-132℃
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| Flash Point |
291.4ºC
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| LogP |
6.693
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
28
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| Complexity |
404
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
CRKGMGQUHDNAPB-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C18H15Cl3N2S.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)212-1(3)4/h1-9,12,18H,10-11H2(H,2,3,4)
|
| Chemical Name |
1-(2-((4-chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole nitrate
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| Synonyms |
Sulconazole RS-44872 RS 44872 RS44872 Exelderm
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~271.29 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.51 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.51 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (4.51 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1703 mL | 10.8516 mL | 21.7033 mL | |
| 5 mM | 0.4341 mL | 2.1703 mL | 4.3407 mL | |
| 10 mM | 0.2170 mL | 1.0852 mL | 2.1703 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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