| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g |
Suprastat is a novel, potent and selective HDAC6 (Histone Deacetylase 6) inhibitor with the ability to potentiate immunotherapy in melanoma. In vitro characterization of Suprastat demonstrates subnanomolar HDAC6 inhibitory potency and a hundred- to a thousand-fold HDAC6 selectivity over the other HDAC isoforms. In vivo studies reveal that a combination of Suprastat and anti-PD1 immunotherapy enhances anti-tumor immune response, mediated by a decrease of pro-tumoral M2 macrophages and increased infiltration of anti-tumor CD8+ effector and memory T-cells.
| References |
J. Med. Chem., Just Accepted Manuscript • DOI: 10.1021/acs.jmedchem.0c00567 • Publication Date (Web): 20 Aug 2020
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| Molecular Formula |
0
|
|---|---|
| Molecular Weight |
179.96896g/mol
|
| CAS # |
90093-40-6
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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