| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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Purity: ≥98%
T-26c is a novel, highly potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13) with an IC50 of 6.75 pM and shows more than 2600-fold selectivity over the other related metalloenzymes. It was discovered using X-ray co-crystal structures of matrix metalloproteinase-13 (MMP-13) in combination with its inhibitors. The goal of the structure-based drug design (SBDD) approach was to achieve high affinity by maximizing the interaction between the protein and the ligand through the specificity pocket of the S1 hydrophobic residue.
| Targets |
MMP-13 (IC50 = 6.75 pM)
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|---|---|
| ln Vitro |
T-26c dramatically reduces the amount of collagen broken down in IL-1β and oncostatin M stimulated cartilage (87.4% inhibition at 0.1 μM)[1].
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| ln Vivo |
T-26c is well absorbed in all species at the oral dose of 10–20 mg/kg. In comparison to the free acid T-26c (AUC = 6478 ng h/mL and Cmax = 911 ng/mL), oral administration of the disodium salt formulations of T-26c to guinea pigs causes significant increases in AUC (8357 ng h/mL) and Cmax (1445 ng/mL)[1].
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| References |
| Molecular Formula |
C24H21N3O6S
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|---|---|
| Molecular Weight |
479.505044698715
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| Exact Mass |
479.12
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| Elemental Analysis |
C, 60.12; H, 4.41; N, 8.76; O, 20.02; S, 6.69
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| CAS # |
869296-13-9
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| Related CAS # |
69298-22-6 (sodium);869296-13-9 (free acid);
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| PubChem CID |
11525848
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| Appearance |
White to off-white solid powder
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| LogP |
2.6
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
9
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| Heavy Atom Count |
34
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| Complexity |
785
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
CDQRIIUMNLMHRH-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C24H21N3O6S/c1-32-18-4-2-3-15(9-18)10-25-22(29)20-26-21(28)19-17(13-34-23(19)27-20)12-33-11-14-5-7-16(8-6-14)24(30)31/h2-9,13H,10-12H2,1H3,(H,25,29)(H,30,31)(H,26,27,28)
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| Chemical Name |
4-[[2-[(3-methoxyphenyl)methylcarbamoyl]-4-oxo-3H-thieno[2,3-d]pyrimidin-5-yl]methoxymethyl]benzoic acid
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| Synonyms |
T-26c; T 26c; T26c
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 15.6~40 mg/mL (32.6~83.4 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.56 mg/mL (3.25 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 15.6 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.56 mg/mL (3.25 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 15.6 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0855 mL | 10.4273 mL | 20.8546 mL | |
| 5 mM | 0.4171 mL | 2.0855 mL | 4.1709 mL | |
| 10 mM | 0.2085 mL | 1.0427 mL | 2.0855 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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