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| 25mg |
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| 50mg |
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Purity: ≥98%
Targocil is a antibiotic, inhibiting a late step in wall teichoic acid biosynthesis and inducing the cell wall stress stimulon in staphylococcus aureus.
| ln Vitro |
The MIC for Targocil in relation to S. Newman, MW2, MG2375, and MG2389 strains of aureus had a concentration of 1 μg/mL. Targocil exhibited outstanding performance in dealing with S. MSSA and MRSA isolates with MICs ranging from 1 to 2 μg/mL were among the aureus isolates from probable instances of bacterial keratitis. Derived from 1835F03, tartagocil has superior efficacy against all isolates of keratitis when compared to the original lead chemical, 1835F03. Bovine serum was found to exhibit a discernible mild reduction of 1835F03 and Targocil's in vitro antibacterial activity, resulting in a 4- to 8-fold increase in their respective MICs. Even after 24 hours of exposure, HCEC found targocil at 5 μg/mL to be only somewhat harmful when compared to the vehicle alone. Nevertheless, at every investigated time point, 40 μg/mL targrocil was hazardous. When HCEC was present, Targocil quickly stopped Newman and MG2375 from growing in vitro at 10×MIC [1].
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| References |
[1]. Suzuki T, et al. In vitro antimicrobial activity of wall teichoic acid biosynthesis inhibitors against Staphylococcus aureus isolates. Antimicrob Agents Chemother. 2011 Feb;55(2):767-74
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| Molecular Formula |
C21H22CLN5O4S
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|---|---|
| Molecular Weight |
475.948
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| Exact Mass |
475.1081
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| Elemental Analysis |
C, 53.00; H, 4.66; Cl, 7.45; N, 14.71; O, 13.45; S, 6.74
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| CAS # |
1200443-21-5
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| Related CAS # |
1200443-21-5
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| Appearance |
Solid powder
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| SMILES |
COC1=CC2=C(C=C1OC)C(N(CC)CC)=NC3=C(S(=O)(C4=CC=C(Cl)C=C4)=O)N=NN32
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| InChi Key |
TYNZGYMGTTUYKZ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C21H22ClN5O4S/c1-5-26(6-2)19-15-11-17(30-3)18(31-4)12-16(15)27-20(23-19)21(24-25-27)32(28,29)14-9-7-13(22)8-10-14/h7-12H,5-6H2,1-4H3
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| Chemical Name |
3-(4-Chlorophenylsulfonyl)-N,N-diethyl-7,8-dimethoxy-[1,2,3]triazolo[1,5-a]quinazolin-5-amine
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| Synonyms |
QC-993; QC 993; QC993; Targocil;
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~33.33 mg/mL (~70.03 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.25 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. Solubility in Formulation 2: 10% DMSO+90% Corn Oil: ≥ 2.5 mg/mL (5.25 mM) (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1011 mL | 10.5053 mL | 21.0106 mL | |
| 5 mM | 0.4202 mL | 2.1011 mL | 4.2021 mL | |
| 10 mM | 0.2101 mL | 1.0505 mL | 2.1011 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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