Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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Purity: ≥98%
TC-DAPK 6 is a novel, potent, ATP-competitive, and highly selective death-associated protein kinase (DAPK) inhibitor with IC50 of 69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 μM ATP.
Targets |
DAPK1 (IC50 = 69 nM); DAPK3 (IC50 = 225 nM)
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ln Vitro |
TC-DAPK 6 is found to be the most potent Death-associated protein kinase (DAPK) inhibitor with enzyme selectivity. The IC50 values for DAPK1 and DAPK3 when measured with 10 μM ATP are 69 and 225 nM, respectively. p70S6K is also inhibited by TC-DAPK 6 (1 μM < IC50< 10 μM)[1].
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References |
Molecular Formula |
C17H12N2O2
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Molecular Weight |
276.29
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Exact Mass |
276.0899
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Elemental Analysis |
C, 73.90; H, 4.38; N, 10.14; O, 11.58
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CAS # |
315694-89-4
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Related CAS # |
315694-89-4
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Appearance |
Solid powder
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SMILES |
C1=CC=C(C=C1)/C=C/C2=N/C(=C/C3=CN=CC=C3)/C(=O)O2
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InChi Key |
GFGMISOSPOPSHN-QCTDOKRBSA-N
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InChi Code |
InChI=1S/C17H12N2O2/c20-17-15(11-14-7-4-10-18-12-14)19-16(21-17)9-8-13-5-2-1-3-6-13/h1-12H/b9-8+,15-11+
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Chemical Name |
(4E)-2-[(E)-2-phenylethenyl]-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5-one
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Synonyms |
TC-DAPK 6; TCDAPK6; TC DAPK 6; DAPK Inhibitor; T6908224; T 6908224; -6908224
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: ~18.7 mg/mL (~67.6 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 2 mg/mL (7.24 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.6194 mL | 18.0969 mL | 36.1939 mL | |
5 mM | 0.7239 mL | 3.6194 mL | 7.2388 mL | |
10 mM | 0.3619 mL | 1.8097 mL | 3.6194 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.