| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ln Vitro |
Against a range of harmful bacteria, tebipenem hydrochloride (0–128 μg/mL, 18–24 h) demonstrates outstanding antibacterial activity [1].
|
|---|---|
| ln Vivo |
Tebipenem hydrochloride (L084) (0-4.00 g/kg; po; once) demonstrated a minimum lethal dose (MLD) of 4.00 g/kg and a maximum tolerated dose (MTD) of 3.40 g in mice /kg[1]. Tebipenem hydrochloride (50 and 100 mg/kg; oral; once) can considerably prevent septic mice challenged with diverse infections [1].
|
| Cell Assay |
Cell Viability Assay[1]
Cell Types: Gram-positive and Gram-negative bacteria Tested Concentrations: 0-128 μg/mL Incubation Duration: 18–24 hrs (hours) Experimental Results: Gram-positive and Gram-negative bacteria tested Shows inhibitory effect with MIC50 below 64 μg/mL - negative bacteria. |
| Animal Protocol |
Animal/Disease Models: KM mice, body weight 18-22 g[1]
Doses: 2.89, 3.40, 4.00 g/kg Route of Administration: oral (tablet), one time Experimental Results:within 14 days of observation period, up to 1 mouse Death oral dose (4.00 g/kg). The minimum lethal dose (MLD) for mice is 4.00 g/kg, and the maximum tolerated dose (MTD) is 3.40 g/kg. Liver and kidney damage is dose-dependent. Animal/Disease Models: ICR mouse, sepsis mouse model [1] Doses: 50 and 100 mg/kg Route of Administration: Oral (tablet), once Experimental Results: Dramatically increased sepsis during the 168-hour observation period Number of surviving mice. |
| References |
| Molecular Formula |
C22H32CLN3O6S2
|
|---|---|
| Molecular Weight |
534.09
|
| CAS # |
211558-19-9
|
| Related CAS # |
Tebipenem;161715-21-5;Tebipenem pivoxil;161715-24-8
|
| Appearance |
Typically exists as solid at room temperature
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8723 mL | 9.3617 mL | 18.7234 mL | |
| 5 mM | 0.3745 mL | 1.8723 mL | 3.7447 mL | |
| 10 mM | 0.1872 mL | 0.9362 mL | 1.8723 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
