Size | Price | Stock | Qty |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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Other Sizes |
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Purity: ≥98%
Telotristat besilate, the besilate salt of telotristat, is an analog of Telotristat ethyl (formerly LX 1032; LX 1606; trade name: Xermelo), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Telotristat ethyl was approved in 2017 to treat carcinoid syndrome diarrhea.
Targets |
Tryptophan hydroxylase
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ln Vitro |
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ln Vivo |
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Animal Protocol |
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References |
Gut.2014 Jun;63(6):928-37.
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Molecular Formula |
C31H28CLF3N6O6S
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Molecular Weight |
705.103835105896
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Exact Mass |
704.14318
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Elemental Analysis |
C, 52.81; H, 4.00; Cl, 5.03; F, 8.08; N, 11.92; O, 13.61; S, 4.55
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CAS # |
1374745-52-4
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Related CAS # |
1137608-69-5 (etiprate);1033805-22-9 (ethyl);1033805-28-5 (acid);1374745-52-4 (besilate);
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PubChem CID |
56962367
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Appearance |
Typically exists as solid at room temperature
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tPSA |
205Ų
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InChi Key |
WYZQOTLDKIRRDC-VNJAQMQMSA-N
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InChi Code |
InChI=1S/C25H22ClF3N6O3.C6H6O3S/c1-13-8-9-35(34-13)20-11-16(26)6-7-17(20)22(25(27,28)29)38-21-12-19(32-24(31)33-21)15-4-2-14(3-5-15)10-18(30)23(36)37;7-10(8,9)6-4-2-1-3-5-6/h2-9,11-12,18,22H,10,30H2,1H3,(H,36,37)(H2,31,32,33);1-5H,(H,7,8,9)/t18-,22+;/m0./s1
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Chemical Name |
(2S)-2-amino-3-[4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl]phenyl]propanoic acid;benzenesulfonic acid
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Synonyms |
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.4182 mL | 7.0912 mL | 14.1824 mL | |
5 mM | 0.2836 mL | 1.4182 mL | 2.8365 mL | |
10 mM | 0.1418 mL | 0.7091 mL | 1.4182 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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