| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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Temocillin disodium salt is a semisynthetic, narrow-spectrum and β-lactamase-resistant penicillin introduced by Beecham, marketed by Eumedica Pharmaceuticals as Negaban. It is used primarily for the treatment of multiple drug-resistant, Gram-negative bacteria. It is a 6-methoxy penicillin; it is also a carboxypenicillin. Temocillin binds to and inactivates penicillin -binding proteins (PBPs) located on the inner membrane of the bacterial cell wall.
| ln Vivo |
With no discernible difference between the parental strain and its transconjugant, temocillin dosage regimens of 200 mg/kg every 4 and 6 hours continued to be highly effective in lowering bacterial titres in kidneys against the two strains[2].
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| References |
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| Additional Infomation |
Temocillin disodium is an organic sodium salt. It contains a temocillin(2-).
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| Molecular Formula |
C16H16N2O7S2-2.2[NA+]
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|---|---|
| Molecular Weight |
458.41704
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| Exact Mass |
414.056
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| CAS # |
61545-06-0
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| Related CAS # |
Temocillin;66148-78-5
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| PubChem CID |
11583399
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.6g/cm3
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| Boiling Point |
761.9ºC at 760mmHg
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| Flash Point |
414.6ºC
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| LogP |
1.3
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
9
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
29
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| Complexity |
689
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| Defined Atom Stereocenter Count |
3
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| SMILES |
[Na+].[Na+].O=C(C(C(N[C@@]1(C(=O)N2[C@H](C(S[C@H]12)(C)C)C([O-])=O)OC)=O)C1C=CSC=1)[O-]
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| InChi Key |
MRGCZDWBFFUEES-CWBCWDDISA-L
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| InChi Code |
InChI=1S/C16H18N2O7S2.2Na/c1-15(2)9(12(22)23)18-13(24)16(25-3,14(18)27-15)17-10(19)8(11(20)21)7-4-5-26-6-7;;/h4-6,8-9,14H,1-3H3,(H,17,19)(H,20,21)(H,22,23);;/q;2*+1/p-2/t8?,9-,14+,16-;;/m0../s1
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| Chemical Name |
disodium;(2S,5R,6S)-6-[(2-carboxylato-2-thiophen-3-ylacetyl)amino]-6-methoxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
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| Synonyms |
Temocillin sodium; temocillin disodium; 96IIP39ODH; disodium
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~250 mg/mL (~545.35 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (109.07 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1814 mL | 10.9070 mL | 21.8141 mL | |
| 5 mM | 0.4363 mL | 2.1814 mL | 4.3628 mL | |
| 10 mM | 0.2181 mL | 1.0907 mL | 2.1814 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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