Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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Other Sizes |
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Teriparatide (HSDB 7367; ZT034; Human parathyroid hormone 1-34; trade name Forteo), a recombinant form of parathyroid hormone (consisting of the first 34 amino acids of PHT), is a potent parathyroid hormone (PTH) agonist that has been approved in 2017 as an anabolic agent for the treatment of some forms of osteoporosis. As a PHT agonist, it inhibits PHT with an IC50 of 2 nM in HEK293 cells.
ln Vivo |
Teriparatide (human parathyroid hormone-(1-34)) (20 μg/kg ih; once daily for 4 weeks; female New Zealand White rabbits) increases body weight and obesity [1].
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Animal Protocol |
Animal/Disease Models: Female New Zealand White rabbit [1]
Doses: 20 μg/kg Route of Administration: subcutaneous injection; one time/day for 4 weeks Experimental Results: Increased porosity, number and density as well as cortical area, thickness and bone mineral content (BMC), but had no significant effect on volumetric bone mineral density (BMD). |
References |
[1]. Iwamoto J, et, al. Influence of Teriparatide and Ibandronate on Cortical Bone in New Zealand White Rabbits: A HR-QCT Study. Calcif Tissue Int. 2016
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Molecular Formula |
C₁₈₁H₂₉₁N₅₅O₅₁S₂
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Molecular Weight |
4117.72
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CAS # |
52232-67-4
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Related CAS # |
Teriparatide acetate hydrate;99294-94-7
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
[SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF]
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Synonyms |
PTH 1-34; HSDB7367; ZT 034; HSDB-7367; ZT034; ZT-034; HSDB 7367; Human parathyroid hormone 1-34; trade name Forteo
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ~100 mg/mL (~24.29 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (12.14 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 0.2429 mL | 1.2143 mL | 2.4285 mL | |
5 mM | 0.0486 mL | 0.2429 mL | 0.4857 mL | |
10 mM | 0.0243 mL | 0.1214 mL | 0.2429 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.