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    Tetrabenazine (Xenazine)
    Tetrabenazine (Xenazine)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1862
    CAS #: 58-46-8 Purity ≥98%

    Description: Tetrabenazine (Ro 1-9569; trade name: Nitoman and Xenazin), a VMAT-inhibitor, is an FDA approved drug for the treatment of symptomatic treatment of hyperkinetic movement disorder.  FDA approved the use of tetrabenazine to treat chorea associated with Huntington's disease (HD) On August 15, 2008, which is the first in the US. The precise mechanism of action of tetrabenazine is unknown. The antichorea effect is believed to be related to its effect as a reversible depletory of monoamines (such as dopamine, serotonin, norepinephrine and histamine)from nerve terminals) 

    References: Neurology. 1997 Feb;48(2):358-62;  Ann Pharmacother. 2011 Apr;45(4):525-31.

    Related CAS#:718635-93-9 (Tetrabenazine Racemate); 1392826-25-3 (Tetrabenazine D6); 1026016-83-0 [Tetrabenazine ((+)-); (+)-Tetrabenazine; (+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine)]; 1977511-05-9 [(+)-Tetrabenazine D6]

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    Molecular Weight (MW)317.42 
    FormulaC19H27NO3 
    CAS No.58-46-8  (free base); 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 58 mg/mL (182.7 mM) 
    Water: <1 mg/mL
    Ethanol: 32 mg/mL (100.8 mM) 
    Technical infoIUPAC/Chemical Name: (3S,11bS)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
    InChi Key: MKJIEFSOBYUXJB-HOCLYGCPSA-N
    InChi Code: InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t14-,16-/m0/s1
    SMILES Code: O=C1[[email protected]@H](CC(C)C)CN2CCC3=CC(OC)=C(OC)C=C3[[email protected]]2([H])C1
    SynonymsTetrabenazine; trade names Nitoman and Xenazin; Ro 1 9569; Ro-1 9569; Ro 1-9569


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