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Purity: ≥98%
Tetracycline HCl (NSC-108579, Sumycin among others) is a potent and broad-spectrum antibiotic used to treat a number of infections such as gram-positive and gram-negative bacteria. This includes acne, cholera, brucellosis, plague, malaria, and syphilis. It possesses some level of bacteriostatic activity against almost all medically relevant aerobic and anaerobic bacterial genera, both Gram-positive and Gram-negative.
| Targets |
Tetracycline
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|---|---|
| ln Vitro |
Tetracyclines are broad-spectrum antibiotics that work against a variety of gram-positive and gram-negative bacteria, as well as protozoan parasites and atypical organisms like chlamydiae, mycoplasmas, and rickettsiae. Tetracyclines stop aminoacyl-tRNA from attaching itself to the bacterial ribosome, which inhibits the synthesis of proteins by bacteria. Through the OmpF and OmpC porin channels, tetracyclines enter gram-negative enteric bacteria's outer membrane as positively charged cations (likely magnesium)-tetracycline coordination complexes [1].
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| ln Vivo |
Tetracyclines are useful for treating infections in pigs, sheep, cattle, and poultry. In certain situations, such as when treating a large number of commercially farmed chickens therapeutically, antibiotics can be given as aerosols or added straight to feed or water. Tetracyclines may be utilized to enhance or promote growth. In aquaculture, tetracyclines are used to manage infections in lobsters, salmon, and catfish[2].
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| References |
| Molecular Formula |
C22H25CLN2O8
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|---|---|
| Molecular Weight |
480.8955
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| Elemental Analysis |
C, 54.95; H, 5.24; Cl, 7.37; N, 5.83; O, 26.62
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| CAS # |
64-75-5
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| Related CAS # |
Tetracycline;60-54-8
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| Appearance |
Solid powder
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| SMILES |
[H][C@@]12C[C@]3(C(C(C4=C(C=CC=C4[C@]3(O)C)O)=O)=C([C@@]1(C(C(C(N)=O)=C([C@H]2N(C)C)O)=O)O)O)
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| InChi Key |
XMEVHPAGJVLHIG-FMZCEJRJSA-N
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| InChi Code |
InChI=1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)1H/t9-,10-,15-,21+,22-/m0./s1
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| Chemical Name |
(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
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| Synonyms |
Achromycin V; Hostacyclin; Sustamycin; Tetrabid; Tetracycline; Topicycline;Tetracycline HCl; Achromycin;
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : 62.5~96 mg/mL ( 129.96 ~199.62 mM)
Water : 50~80 mg/mL (~103.97 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.33 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.33 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: 10% DMSO+40% PEG300+5% Tween-80+45% Saline: ≥ 2.08 mg/mL (4.33 mM) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0794 mL | 10.3972 mL | 20.7943 mL | |
| 5 mM | 0.4159 mL | 2.0794 mL | 4.1589 mL | |
| 10 mM | 0.2079 mL | 1.0397 mL | 2.0794 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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