Size | Price | Stock | Qty |
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10mg |
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50mg |
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Other Sizes |
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ln Vivo |
The Chinese herbal remedy Corydalis tetrahydraceae has an active component called tetrahydropyridine (THP), which has analgesic properties. The following activity measures were significantly impacted by picrotoxin treatment alone: freezing times (Financial Times), clockwise and counterclockwise rotations (CT and ACT), increases in horizontal movement times (HMT and VMT), and decreases in freezing times. HMT, VMT, and total distance traveled (TDT) decreased with tetrahydrolate treatment alone, although FT increased. Tetrahydrocyridine injections intraperitoneally at doses of 10 mg/kg or 15 mg/kg; the augmentation of HMT, VMT, CT, ACT, and TDT and the decrease in FT caused by picrotoxin were significantly separated by dose impairment. Eight animals were set aside in each of the six groups that were created by randomly short-circuiting the remaining 48 traps while they were sedated with ethyl benzoate. Dopamine (DA) amygdala release was enhanced by subcutaneous injection of picrotoxin, but there was no discernible change in DA amygdala release following intraperitoneal injection of 10 mg/kg tetrahydrocyridine. Similarly, giving tetrahydropyridine half an hour prior to subcutaneous injection of picrotoxin virtually eliminated increases in DA amygdala release caused by picrotoxin [1].
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References |
[1]. Chang CK, et al. DL-Tetrahydropalmatine may act through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats. Neurosci Lett. 2001 Jul 20;307(3):163-6
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Molecular Formula |
C21H25NO4
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Molecular Weight |
355.4275
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CAS # |
2934-97-6
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Related CAS # |
Rotundine;483-14-7;Tetrahydropalmatine hydrochloride;6024-85-7
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
O(C([H])([H])[H])C1=C(C([H])=C([H])C2=C1C([H])([H])N1C([H])([H])C([H])([H])C3=C([H])C(=C(C([H])=C3C1([H])C2([H])[H])OC([H])([H])[H])OC([H])([H])[H])OC([H])([H])[H]
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~6.67 mg/mL (~18.77 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.67 mg/mL (1.89 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 6.7 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.8135 mL | 14.0675 mL | 28.1349 mL | |
5 mM | 0.5627 mL | 2.8135 mL | 5.6270 mL | |
10 mM | 0.2813 mL | 1.4067 mL | 2.8135 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.