Size | Price | Stock | Qty |
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5mg |
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10mg |
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50mg |
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100mg |
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Other Sizes |
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ln Vitro |
The common ingredient in human serum and amniotic fluid is thyroxine sulfate (T4S). It is mostly produced by peripheral thyroxine and builds up when fetal type I 5-monodeiodination activity is low or is suppressed by medication, like iodates [1].
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ln Vivo |
Thyroxine sulfate (T4S) has been found in significant concentrations in fetal sheep serum, bile, meconium, amniotic fluid, and allantoic fluid. T4S concentration in women's amniotic fluid at eighteen (19) and fifteen (15) weeks of gestation (25.5 ng/dL and 14.3 ng/dL, respectively). One day after ingesting one gram of ipodate, patients with hyperthyroidism showed a substantial increase in plasma T4S [1]. Prostaglandins are heavily sulfated in the body; biliary excretion of T4S is increased if their type I demyocardial actions are prevented [2]. A decreased demyocardial action of myocardial D1 during critical illness appears to play a role in the increased serum T4S levels, which were considerably higher than those of healthy subjects. function [3].
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References |
[1]. Wu SY, et al. Identification of thyroxine-sulfate (T4S) in human serum and amniotic fluid by a novel T4S radioimmunoassay. Thyroid. 1992 Summer;2(2):101-5.
[2]. Rutgers M, et al. Effects of propylthiouracil on the biliary clearance of thyroxine (T4) in rats: decreased excretion of 3,5,3'-triiodothyronine glucuronide and increased excretion of 3,3',5'-triiodothyronine glucuronide and T4 sulfate. Endocrinology. 1989 Oct;125(4):2175-86. [3]. Peeters RP, et al. Increased thyroxine sulfate levels in critically ill patients as a result of a decreased hepatic type Ideiodinase activity. J Clin Endocrinol Metab. 2005 Dec;90(12):6460-5. |
Molecular Formula |
C15H11I4NO7S
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Molecular Weight |
856.93
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Exact Mass |
856.6435
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CAS # |
77074-49-8
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Related CAS # |
L-Thyroxine;51-48-9;L-Thyroxine sodium salt pentahydrate;6106-07-6
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
N[C@@H](CC1=CC(I)=C(C(I)=C1)OC2=CC(I)=C(OS(=O)(O)=O)C(I)=C2)C(O)=O
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Synonyms |
T4 Sulfate; Thyroxine sulfate
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~140 mg/mL (~163.37 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 5.75 mg/mL (6.71 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 57.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 5.75 mg/mL (6.71 mM) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 57.5 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. View More
Solubility in Formulation 3: ≥ 2.58 mg/mL (3.01 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.1670 mL | 5.8348 mL | 11.6696 mL | |
5 mM | 0.2334 mL | 1.1670 mL | 2.3339 mL | |
10 mM | 0.1167 mL | 0.5835 mL | 1.1670 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.