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Purity: ≥98%
Ticlopidine HCl (Ticlodix; Ticlodone; 53-32C; 5332C; trade name Ticlid), the hydrochloride salt of ticlopidine, is a potent P2 receptor inhibitor against used as antiplatelet and anticoagulant. It inhibits ADP-induced platelet aggregation with an IC50 of ~2 μM. Ticlopidine is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. Initial research showed that Ticlopidine was useful for preventing strokes and coronary stent occlusions. However, due to its serious side effects of neutropenia and thrombotic thrombocytopenic purpura, Ticlopidine was primarily used in patients in whom aspirin was not tolerated, or in whom dual antiplatelet therapy was desirable.
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| References |
Clin Pharmacol Ther.1975 Oct;18(4):485-90;Thromb Haemost.1979 Apr 23;41(2):436-49.
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| Molecular Formula |
C14H14CLNS.HCL
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|---|---|
| Molecular Weight |
300.25
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| CAS # |
53885-35-1
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| Related CAS # |
55142-85-3
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| SMILES |
C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl.Cl
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| InChi Key |
MTKNGOHFNXIVOS-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C14H14ClNS.ClH/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14;/h1-4,6,8H,5,7,9-10H2;1H
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| Chemical Name |
5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride
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| Synonyms |
Ticlodix; Ticlodone; Ticlopidine; Ticlopidine HCl; 53 32C; 53-32C; 5332C; trade name Ticlid
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3306 mL | 16.6528 mL | 33.3056 mL | |
| 5 mM | 0.6661 mL | 3.3306 mL | 6.6611 mL | |
| 10 mM | 0.3331 mL | 1.6653 mL | 3.3306 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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