| Size | Price | Stock | Qty |
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| 500mg |
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| 1g |
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| 2g |
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| 5g |
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| Other Sizes |
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Ligustrazine (TMP; Chuanxiongzine; Tetramethylpyrazine) is an naturally occurring alkylpyrazine isolated from Ligusticum chuanxiong Hort. (Chuan Xiong) with potential nootropic and anti-inflammatory activities. It acts as a blocker of TFAM degradation, up-regulating mitochondrial DNA copy number by interacting with TFAM. Ligustrazine (Chuanxiongzine HCl; Tetramethylpyrazine) is a natural product a natural product with protective effects against injured ECV304 cells. It can significantly increase NOS and NO formation compared with the model group.
| ln Vitro |
For about 40 years, ligentazine has been extensively utilized in my nation to treat cardiovascular and cerebrovascular illnesses. because it works well in many systems, including the heart. Ligustrazine is also used to treat a number of illnesses, including liver damage, diabetes, cancer, and coronary heart disease [1].
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| References |
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| Additional Infomation |
Tetramethylpyrazine is a member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii). It has a role as an antineoplastic agent, an apoptosis inhibitor, a neuroprotective agent, a vasodilator agent, a platelet aggregation inhibitor and a bacterial metabolite. It is a member of pyrazines and an alkaloid.
2,3,5,6-Tetramethylpyrazine has been reported in Francisella tularensis, Camellia sinensis, and other organisms with data available. |
| Molecular Formula |
C8H12N2
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|---|---|
| Molecular Weight |
136.198
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| Exact Mass |
136.1
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| CAS # |
1124-11-4
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| Related CAS # |
Ligustrazine hydrochloride;76494-51-4
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| PubChem CID |
14296
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| Appearance |
White to off-white solid powder
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
192.7±35.0 °C at 760 mmHg
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| Melting Point |
77-80 °C(lit.)
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| Flash Point |
71.6±17.6 °C
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| Vapour Pressure |
0.7±0.4 mmHg at 25°C
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| Index of Refraction |
1.504
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| LogP |
1.56
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
10
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| Complexity |
87.8
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
FINHMKGKINIASC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3
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| Chemical Name |
2,3,5,6-tetramethylpyrazine
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| Synonyms |
Ligustrazine Chuanxiongzine Tetramethylpyrazine TMP
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~367.13 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (18.36 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (18.36 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (18.36 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.3421 mL | 36.7107 mL | 73.4214 mL | |
| 5 mM | 1.4684 mL | 7.3421 mL | 14.6843 mL | |
| 10 mM | 0.7342 mL | 3.6711 mL | 7.3421 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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