| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
Total reactive oxygen species in human brain-derived cells (U-87 MG) are impacted by TP-10 (10 μg/mL; 24 hours) [3].
|
|---|---|
| ln Vivo |
On cyclic nucleotides, TP-10 (0.1–10 mg/kg; once an hour) has demonstrated effects [2].
|
| Cell Assay |
Cell viability assay [3]
Cell Types: U-87 MG Cell Tested Concentrations: 10 μg/ml Incubation Duration: 24 hrs (hours) Experimental Results: The total number of ROS-positive cells diminished, and there was no toxic effect on U-87 MG cells. |
| Animal Protocol |
Animal/Disease Models: Male CD rat [2]
Doses: 0.1, 0.32, 1.0, 3.2 and 10 mg/kg Route of Administration: subcutaneous injection; 0.1-10 mg/kg One-time Experimental Results: Dose- and time-dependent increase in striae in mice cGMP and cAMP levels in the body. Three hrs (hrs (hours)) after injection at a dose of 3.2 mg/kg, pCREB-LI levels first increased and returned to basal levels. |
| References |
|
| Molecular Formula |
C26H19N4OF3
|
|---|---|
| Molecular Weight |
460.45046
|
| Exact Mass |
460.151
|
| CAS # |
898563-00-3
|
| PubChem CID |
11648276
|
| Appearance |
Light yellow to brown solid powder
|
| LogP |
6.301
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
7
|
| Rotatable Bond Count |
6
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| Heavy Atom Count |
34
|
| Complexity |
636
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
NOIXNOMHHWGUTG-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C26H19F3N4O/c27-26(28,29)17-33-15-23(18-11-13-30-14-12-18)25(32-33)20-6-9-22(10-7-20)34-16-21-8-5-19-3-1-2-4-24(19)31-21/h1-15H,16-17H2
|
| Chemical Name |
2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~217.18 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (5.43 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.43 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. View More
Solubility in Formulation 3: ≥ 2.38 mg/mL (5.17 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1718 mL | 10.8589 mL | 21.7179 mL | |
| 5 mM | 0.4344 mL | 2.1718 mL | 4.3436 mL | |
| 10 mM | 0.2172 mL | 1.0859 mL | 2.1718 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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