Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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Other Sizes |
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Purity: ≥98%
Travoprost (also known as Fluprostenol isopropyl ester; AL6221; Flu-Ipr; brand name Travatan) is medication used to treat high pressure inside the eye including glaucoma. It is specifically used in cases where other agents are insufficient for open angle glaucoma. It's applied as an ocular drop. In most cases, effects happen in two hours.
Targets |
FP
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ln Vitro |
Travoprost has affinity for the IP, TP, DP, EP1, EP3, and EP4 receptors that is sub-micromolar[1].
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ln Vivo |
At a dose of 1 μg, travoprost causes less ocular irritation in the New Zealand albino (NZA) rabbit than PGF20 isopropyl ester. Travoprost applied topically to the eyes causes a noticeable miotic effect in cats after doses of 0.01, 0.03, and 0.1 μg. Applying 0.1 and 0.3 μg of travoprost orally every day resulted in a peak reduction of 22.7% and 28.6% in intraocular pressure (IOP) in the ocular hypertensive monkey. Travoprost applied topically to rabbits, cats, and monkeys did not result in ocular irritation or discomfort at doses up to 1 μg[1].
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References |
Molecular Formula |
C26H35F3O6
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Molecular Weight |
500.5477
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Exact Mass |
500.24
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Elemental Analysis |
C, 62.39; H, 7.05; F, 11.39; O, 19.18
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CAS # |
157283-68-6
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Related CAS # |
5,6-trans-Travoprost; 1563176-59-9
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Appearance |
Oil like
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SMILES |
CC(C)OC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](COC2=CC=CC(=C2)C(F)(F)F)O)O)O
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InChi Key |
MKPLKVHSHYCHOC-AHTXBMBWSA-N
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InChi Code |
InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1
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Chemical Name |
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate
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Synonyms |
Fluprostenol isopropyl ester; AL6221; Flu-Ipr; Travatan; Travatan Z; Travoprost
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
Ethanol: ~60 mg/mL (~119.9 mM)
DMSO: ≥ 41.67 mg/mL (~83.3 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.16 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.16 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (4.16 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.9978 mL | 9.9890 mL | 19.9780 mL | |
5 mM | 0.3996 mL | 1.9978 mL | 3.9956 mL | |
10 mM | 0.1998 mL | 0.9989 mL | 1.9978 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
NCT05335122 | Active Recruiting |
Drug: OTX-TIC low dose Travoprost Intracameral Implant Drug: OTX-TIC high dose Travoprost Intracameral Implant |
Open Angle Glaucoma Ocular Hypertension |
Ocular Therapeutix, Inc. | March 16, 2022 | Phase 2 |
NCT03868124 | Active Recruiting |
Combination Product: G2-TR intraocular implant containing travoprost Drug: Sham surgery + active -comparator eye drops |
Glaucoma, Open-Angle Ocular Hypertension |
Messoud Ashina, MD | June 30, 2022 | Phase 4 |
NCT03519386 | Active Recruiting |
Combination Product: G2-TR intraocular implant containing Drug: Sham surgery + active-comparator eye drops |
Glaucoma, Open-Angle Ocular Hypertension |
Glaukos Corporation | July 26, 2018 | Phase 3 |
NCT02390284 | Active Recruiting |
Drug: Latanoprost Drug: Bimatoprost Drug: Travoprost |
Glaucoma | University of Miami | September 2015 | Phase 3 |