Trazodone HCl (AF-116;, KB-831)

Alias: AF-1161; KB-831; KB 831; KB831; Trazodone; Trazodon; Beneficat; AF 1161; AF1161; Trazodone HCl

Cat No.:V0986 Purity: ≥98%

COA Product Data Instructions for use SDS

Trazodone HCl (AF-116;, KB-831) Chemical Structure CAS No.: 25332-39-2
Product category: 5-HT Receptor

This product is for research use only, not for human use. We do not sell to patients.

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Other Forms of Trazodone HCl (AF-116;, KB-831):

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Top Publications Citing lnvivochem Products

Nature 2021, 597(7874):119-125.

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Science Trans Med 2023,15(701):eadd7872.

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Cancer Cell 2021,39(4):529-547.e7.

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Immunity 2023,56(3):620-634.e11.

J Am Chem Soc 2022,144:21831-21836.

Cell 2020,183:1202-1218.e25.

Science Adv 2022:8,eabm9427.

Nature 2021,597(7874):119-125.

Cell 2020,183:1202-1218.e25.

PNAS Nexus 2022,1(3):pgac063.

ACS Nano 2023,17(10):9110-9125.

Biomaterial 2023 Sep16:302:122333.

Purity & Quality Control Documentation

Current batch：

Purity: ≥98%

COA

MSDS

Instructions

Product Description
Bioactivity & Protocols
Physicochemical Properties
Solubility Data
Calculators
Clinical Trial Information
Biological Data

Product Description

Trazodone HCl (Beneficat, KB 831, KB831, AF 1161, AF1161), the hydrochloride salt of Trazodone, is an approved antidepressant drug of the class of serotonin receptor antagonists and reuptake inhibitors (SARI) with the potential for treatment of anxiety disorders. It has anti-anxiety (anxiolytic) and sleep-inducing (hypnotic) properties. It is chemically a phenylpiperazine analog. It differs significantly from the original antidepressants, such as tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs), in terms of side-effect profile and potential toxicity.

Biological Activity I Assay Protocols (From Reference)

Targets	5-HT Receptor
References	[1]. Trazodone. A review of its pharmacology, therapeutic use in depression and therapeutic potential in other disorders. Drugs Aging, 1994. 4(4): p. 331-55.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Physicochemical Properties

Molecular Formula

C19H23CL2N5O

Molecular Weight

408.32

Exact Mass

371.15

Elemental Analysis

C, 55.89; H, 5.68; Cl, 17.36; N, 17.15; O, 3.92

CAS #

25332-39-2

Related CAS #

Trazodone-d6 hydrochloride; 1181578-71-1; Trazodone; 19794-93-5

Appearance

White to off-white crystalline powder

SMILES

C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl.Cl

InChi Key

OHHDIOKRWWOXMT-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H22ClN5O.ClH/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25;/h1-3,5-7,9,15H,4,8,10-14H2;1H

Chemical Name

2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one;hydrochloride

Synonyms

AF-1161; KB-831; KB 831; KB831; Trazodone; Trazodon; Beneficat; AF 1161; AF1161; Trazodone HCl

HS Tariff Code

2934.99.9001

Storage

Powder -20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Shipping Condition

Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Solubility Data

Solubility (In Vitro)

DMSO: 4~16.7 mg/mL (9.8~40.8 mM)

Water: <1 mg/mL

Ethanol: <1 mg/mL

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.4491 mL	12.2453 mL	24.4906 mL
	5 mM	0.4898 mL	2.4491 mL	4.8981 mL
	10 mM	0.2449 mL	1.2245 mL	2.4491 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

Mass

Concentration

Volume

Molecular Weight*

Calculate Reset

Molarity Calculator allows you to calculate the mass, volume, and/or concentration required for a solution, as detailed below:

Calculate the Mass of a compound required to prepare a solution of known volume and concentration
Calculate the Volume of solution required to dissolve a compound of known mass to a desired concentration
Calculate the Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?

Enter 350.26 in the Molecular Weight (MW) box
Enter 10 in the Concentration box and choose the correct unit (mM)
Enter 5 in the Volume box and choose the correct unit (mL)
Click the “Calculate” button
The answer of 17.513 mg appears in the Mass box. In a similar way, you may calculate the volume and concentration.

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculate Reset

Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:

Enter 10 into the Concentration (Start) box and choose the correct unit (mM)
Enter 25 into the Concentration (End) box and select the correct unit (mM)
Enter 25 into the Volume (End) box and choose the correct unit (mL)
Click the “Calculate” button
The answer of 62.5 μL (0.1 ml) appears in the Volume (Start) box

Molecular formula

Total molecular weight

g/mol

Calculate Reset

Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4 c12h18n3o4
Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter the chemical/molecular formula and click the “Calculate’ button.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (or molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate Reset

Reconstitution Calculator allows you to calculate the volume of solvent required to reconstitute your vial.

Enter the mass of the reagent and the desired reconstitution concentration as well as the correct units
Click the “Calculate” button
The answer appears in the Volume (to add to vial) box

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)

Dosage mg/kg

Average weight of animals g

Dosing volume per animal μL

Number of animals

Step 2: Enter in vivo formulation (This is only a calculator, not the exact formulation for a specific product. Please contact us first if there is no in vivo formulation in the solubility section.)

% DMSO

% Tween 80

% ddH₂O

Calculate Reset

Calculation results

Working concentration： mg/mL；

Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O，mix and clarify.

Note： (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

Clinical Trial Information

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04468776	Active Recruiting	Drug: Zolpidem Drug: Trazodone	Chronic Insomnia	California Pacific Medical Center Research Institute	February 25, 2022	Phase 4
NCT05307003	Recruiting	Drug: Trazodone Drug: Quetiapine	Delirium Psych	University of Southern California	April 1, 2023	N/A
NCT05299398	Not yet recruiting	Drug: Trazodone Drug: Placebo	Postpartum Depression	Verinder Sharma	September 1, 2022	Phase 1
NCT05085808	Not yet recruiting	Drug: Trazodone Drug: Quetiapine	Delirium Morality	University of Southern California	March 1, 2024	Phase 4
NCT03668041	Recruiting	Drug: Trazodone Drug: Eszopiclone	Insomnia	VA Office of Research and Development	February 25, 2021	Phase 3

Biological Data

Electrocardiogram showing second-degree Mobitz type 1 atrioventricular block.Am J Case Rep.2015May 27;16:319-21.
Telemetry showing second-degree Mobitz type 1 atrioventricular block recurring after every few beats of normal atrioventricular conduction.Am J Case Rep.2015May 27;16:319-21.
Telemetry showing resolution of frequent second-degree Mobitz type 1 atrioventricular block.Am J Case Rep.2015May 27;16:319-21.