| Size | Price | Stock | Qty |
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| 500mg |
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| 1g |
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| 2g |
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| 5g |
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| 10g |
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| 25g |
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| Other Sizes |
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Purity: ≥98%
| Targets |
Bacterial
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|---|---|
| ln Vitro |
Rat thymocytes exposed to 300 µM H2O2 have greater cytotoxicity when treated with triclocarban (300 nM). Triclocarban (300 nM) promotes the process of H2O2-induced cell death, which leads to an additional increase in the population of dead cells[1]. It does not itself increase the population of death cells. Triclocarban exhibits its estrogenic effects by stimulating luciferase activity in an ER reporter gene assay, encouraging MCF-7 cell proliferation, up-regulating pS2 expression, and down-regulating ERα expression in MCF-7 cells at both the mRNA and protein levels.
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| ln Vivo |
Human subjects' use of soap during showering causes triclocarbaban to be absorbed significantly; its Cmax in their whole blood ranges from 23 nM to 530 nM[1]. Exposure to triclocarban during gestation does not impact a mother's ability to carry her offspring to term, but exposure to triclocarban during lactation negatively impacts the offspring's survival[3].
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| Animal Protocol |
Rats: In three experiments that limited exposure to critical growth periods—gestation, gestation and lactation, or lactation only (cross-fostering)—Sprague Dawley rats are given control, 0.2% weight/weight (w/w), or 0.5% w/w triclocarban-supplemented chow. The goal was to identify the susceptible windows of exposure for developmental consequences.[3]
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| References |
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| Molecular Formula |
C13H9CL3N2O
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|---|---|
| Molecular Weight |
315.5824
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| Exact Mass |
313.98
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| Elemental Analysis |
C, 49.48; H, 2.87; Cl, 33.70; N, 8.88; O, 5.07
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| CAS # |
101-20-2
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| Related CAS # |
Triclocarban-d4;1219799-29-7
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| Appearance |
Solid powder
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| SMILES |
ClC1=CC=C(C=C1)NC(NC2=CC=C(C(Cl)=C2)Cl)=O
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| InChi Key |
ICUTUKXCWQYESQ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C13H9Cl3N2O/c14-8-1-3-9(4-2-8)17-13(19)18-10-5-6-11(15)12(16)7-10/h1-7H,(H2,17,18,19)
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| Chemical Name |
Carbanilide, 3,4,4'-trichloro-
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| Synonyms |
3,4,4′-Trichlorocarbanilide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : 63100 mg/mL ( 199.63~316.88 mM )
Ethanol : ~5 mg/mL |
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| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (7.92 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (7.92 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.92 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (7.92 mM) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1688 mL | 15.8438 mL | 31.6877 mL | |
| 5 mM | 0.6338 mL | 3.1688 mL | 6.3375 mL | |
| 10 mM | 0.3169 mL | 1.5844 mL | 3.1688 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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