| Size | Price | Stock | Qty |
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| 500mg |
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| 1g |
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| 5g |
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| Other Sizes |
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| ln Vitro |
It has been demonstrated that trolox shields cardiac cells from oxidative damage that bridges. In cell tests in a canine model where left anterior descending coronary artery (LAD) blockage was given for two hours and then for four hours, trolox was found to be efficient in preventing muscle cell death [1]. Trolox shields thymocytes against oxidative induction. H2O2-induced DNA fragmentation is reduced to control levels or lower by removal or Trolox post-treatment of cells [2]. Trolox is a hydrophilic derivative of alpha-tocopherol that has been shown to improve vitamin E's scavenging efficiency of peroxide-activated proteins in phosphosomes and lauryl sulfate micelles. Trolox shields the mitochondria of red blood cells from azo agonist exposure and considerably extends the duration for which myocardial and hepatic cells resist xanthine oxidase and hypoxanthine-generated oxygen induction [3].
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| References |
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| Additional Infomation |
Trolox is a chromanol that is 6-hydroxychromane which is substituted by a carboxy group at position 2 and by methyl groups at positions 2, 5, 7, and 8. A cell-permeable, water-soluble analogue of vitamin E, it is used as a standard for measuring the antioxidant capacity of complex mixtures. It has a role as an antioxidant, a radical scavenger, a Wnt signalling inhibitor, a neuroprotective agent and a ferroptosis inhibitor. It is a chromanol, a member of phenols and a monocarboxylic acid.
Trolox has been reported in Penicillium citrinum, Punica granatum, and other organisms with data available. |
| Molecular Formula |
C14H18O4
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|---|---|
| Molecular Weight |
250.2903
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| Exact Mass |
250.12
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| CAS # |
53188-07-1
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| Related CAS # |
(R)-Trolox;53101-49-8;(S)-Trolox;53174-06-4
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| PubChem CID |
40634
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| Appearance |
Off-white to gray solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
450.3±45.0 °C at 760 mmHg
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| Melting Point |
187-189ºC(lit.)
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| Flash Point |
171.0±22.2 °C
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| Vapour Pressure |
0.0±1.2 mmHg at 25°C
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| Index of Refraction |
1.568
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| LogP |
3.01
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
18
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| Complexity |
343
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
GLEVLJDDWXEYCO-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)
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| Chemical Name |
6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carboxylic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~399.54 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (8.31 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (8.31 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (8.31 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9954 mL | 19.9768 mL | 39.9537 mL | |
| 5 mM | 0.7991 mL | 3.9954 mL | 7.9907 mL | |
| 10 mM | 0.3995 mL | 1.9977 mL | 3.9954 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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