Size | Price | Stock | Qty |
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250mg |
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500mg |
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1g |
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2g |
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5g |
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Other Sizes |
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Purity: ≥98%
Trospium chloride (IP-631; IP 631;Sanctura; Trosec; Regurin; Flotros; Tropez OD; Spasmex; Spasmoly) is a potent and competitive muscarinic cholinergic receptor antagonist and a medication used to treat overactive bladder. It antagonizes the effect of acetylcholine on muscarinic receptors in cholinergically innervated organs including the bladder. Its parasympatholytic action reduces the tonus of smooth muscle in the bladder. Receptor assays showed that trospium chloride has negligible affinity for nicotinic receptors as compared to muscarinic receptors at concentrations obtained from therapeutic doses.
ln Vitro |
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ln Vivo |
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Animal Protocol |
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References |
Int J Clin Pract.2010 Oct;64(11):1535-40;Ann Pharmacother.2009 Feb;43(2):283-95.
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Molecular Formula |
C25H30NO3.CL
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Molecular Weight |
427.96
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CAS # |
10405-02-4
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Related CAS # |
Trospium-d8 chloride
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
O=C(C(C1=CC=CC=C1)(O)C2=CC=CC=C2)O[C@@H]3C[C@H]([N+]45CCCC4)CC[C@H]5C3.[Cl-]
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Synonyms |
IP631; Trospium chloride, IP-631; IP 631; trade name Sanctura; Tropez OD; Trosec; Regurin; Flotros; Spasmex; Spasmoly.
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.84 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.84 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (5.84 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 100 mg/mL (233.67 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.3367 mL | 11.6833 mL | 23.3667 mL | |
5 mM | 0.4673 mL | 2.3367 mL | 4.6733 mL | |
10 mM | 0.2337 mL | 1.1683 mL | 2.3367 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
NCT03709992 | Suspended | Drug: Trospium Chloride Drug: Tamsulosin |
Ureter Stone Quality of Life Ureter Obstruction |
Mansoura University | December 18, 2020 | Not Applicable |
NCT06346522 | Recruiting | Drug: Gabapentin (Gaptin ®) 400mg oral capsule once Drug: Trospium chloride slow release (Trospikan ® SR) 60mg oral capsule |
Catheter-related Bladder Discomfort (CRBD) |
Ain Shams University | February 24, 2024 | Phase 4 |
NCT02831231 | Completed | Drug: xanomeline tartrate Drug: Trospium chloride |
Schizophrenia | Karuna Therapeutics | September 7, 2016 | Phase 1 |
NCT00986401 | Completed Has Results | Drug: Trospium Chloride (Sanctura XR®) Drug: Metformin hydrochloride (Glucophage®) |
Healthy | Allergan | October 2009 | Phase 1 |
NCT00863551 | Completed Has Results | Drug: Trospium Chloride | Elderly Pharmacokinetics Overactive Bladder |
Allergan | April 2009 | Phase 4 |