| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| Other Sizes |
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| ln Vitro |
Coenzyme Q10 is a crucial component of every cell's mitochondrial respiratory chain. As a result, it plays a crucial role in the synthesis of adenosine triphosphate (ATP), which serves as the energy source for the majority of biological functions. Within the Golgi apparatus, mitochondria, lysosomes, and plasma membranes, coenzyme Q10 reacts directly with free radicals or restores tocopherol and ascorbic acid from their oxidized states to produce antioxidant effects [1]. Since coenzyme Q10 is widely acknowledged as a vital ingredient that promotes human health, it is a well-liked dietary supplement. Because of its essential role in mitochondrial function and cellular bioenergetics, CoQ10 has been proposed as a therapeutic agent for a range of disorders affecting the cardiovascular system, degenerative neurological system, and neuromuscular system [2].
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| ln Vivo |
Dietary CoQ10 absorbs slowly and to a limited extent because of its hydrophobic nature and large molecular weight. Dissolved CoQ10 formulations exhibit superior bioavailability when it comes to dietary supplements. Tmax is roughly six hours, and elimination half-life is roughly thirty-three hours. In healthy individuals, the plasma coenzyme Q10 reference interval spans 0.40 to 1.91 mM. There is a rather significant relationship between the increase in plasma CoQ10 and the dose taken in the case of CoQ10 supplements. Research on animals shows that all organs, including the heart and brain mitochondria, absorb high quantities of CoQ10 [2]. CoQ10 treatment led to a substantial rise in CoQ10 concentrations in cerebral cortical mitochondria in 12-month-old rats. A transgenic mouse model of familial amyotrophic lateral sclerosis has a much longer lifespan when coenzyme Q10 is given orally, and it also significantly reduces the striatal damage caused by systemic treatment of 3-nitropropionic acid [3].
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| References |
[1]. Yang YK, et al. Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction. Clin Chim Acta. 2015 Oct 23;450:83-9.
[2]. Bhagavan HN, et al. Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res. 2006 May;40(5):445-53. [3]. Matthews RT, et al. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8892-7 |
| Molecular Formula |
C59H90O4
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|---|---|
| Molecular Weight |
863.36
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| Exact Mass |
862.6839
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| CAS # |
303-98-0
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| Related CAS # |
Coenzyme Q10-d6;110971-02-3;Coenzyme Q10-d9;2687960-97-8
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| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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| SMILES |
O=C1C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=C(C)C(C(OC)=C1OC)=O
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| Synonyms |
Ubidecarenone Vitamin Q COQ10 ubiquinone coenzyme Q Coenzyme Q10
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. (2). This product is not stable in solution, please use freshly prepared working solution for optimal results. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMF : 20 mg/mL (~23.17 mM)
Ethanol : ~2.5 mg/mL (~2.90 mM) DMSO : ~1 mg/mL (~1.16 mM) H2O : < 0.1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 3 mg/mL (3.47 mM) in 10% DMF 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: 13.33 mg/mL (15.44 mM) in 20% HP-β-CD in Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.1583 mL | 5.7913 mL | 11.5827 mL | |
| 5 mM | 0.2317 mL | 1.1583 mL | 2.3165 mL | |
| 10 mM | 0.1158 mL | 0.5791 mL | 1.1583 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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