| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
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| Targets |
TNF-α
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|---|---|
| ln Vitro |
RAW 264.7 macrophages are transfected with the appropriate reporter assay plasmids, pretreated with UTL-5g at 1, 10, or 50 µM for 60 min, and then challenged with 100 ng/ml LPS. Transcription factor activity is assessed after a 16-hour incubation. UTL-5g disrupts transcription factors when they exhibit a dose-dependent decline in activity in two experiments.
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| ln Vivo |
UTL-5g (GBL-5g) reduces TGF-β and TNF-α levels that have been raised by lung irradiation[1].
UTL-5g (60 mg/kg; p.o.; daily for 4 days) exhibits beneficial effects in boosting survival rates and lengthening survival times[3]. |
| References |
| Molecular Formula |
C11H8CL2N2O2
|
|---|---|
| Molecular Weight |
271.09
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| Exact Mass |
269.996
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| Elemental Analysis |
C, 48.74; H, 2.97; Cl, 26.15; N, 10.33; O, 11.80
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| CAS # |
646530-37-2
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| Related CAS # |
646530-37-2
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| PubChem CID |
17173847
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| Appearance |
White to off-white solid powder
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| LogP |
3.615
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
17
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| Complexity |
291
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CC1=CC(=NO1)C(=O)NC2=C(C=C(C=C2)Cl)Cl
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| InChi Key |
ULPKSWAQDCJLMN-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C11H8Cl2N2O2/c1-6-4-10(15-17-6)11(16)14-9-3-2-7(12)5-8(9)13/h2-5H,1H3,(H,14,16)
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| Chemical Name |
N-(2,4-dichlorophenyl)-5-methyl-1,2-oxazole-3-carboxamide
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| Synonyms |
UTL5g; UTL 5g; UTL-5g
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| HS Tariff Code |
2934.99.03.00
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 54~100 mg/mL(199.2~368.9 mM)
Ethanol~ ~4 mg/mL(14.8 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.22 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6888 mL | 18.4441 mL | 36.8881 mL | |
| 5 mM | 0.7378 mL | 3.6888 mL | 7.3776 mL | |
| 10 mM | 0.3689 mL | 1.8444 mL | 3.6888 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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