| Size | Price | Stock | Qty |
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| 250mg |
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| 500mg |
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| 1g |
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| 2g |
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| Other Sizes |
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Visnagin is naturally occurring furanocoumarin isolated from A. visnaga with antioxidant, anti-inflammatory and analgesic activity. Visnagin can prevent Cerulein induced acute pancreatitis (AP).
| ln Vitro |
HepG2 cells exposed to visnagin (10 µM; 4, 8, 16, 24 hours) exhibit CYP1A1 transcription induction [1]. MNF (3'-methoxy-4'-nitroflavone; 20 µM; pretreatment 1 hour) effectively counteracts this induction, while visnagin (10 µM; for 16 hours) increases CYP1B1 gene expression in an aryl hydrocarbon receptor (AHR)-dependent manner. In an AHR-dependent way, visnagin also increases PAI-2 transcription [1].
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| ln Vivo |
Visnagin (10, 30, 60 mg/kg; intraperitoneally; for 7 days) efficiently lowers plasma levels of lipase and amylase, and lowers Cerulein (50 μg/kg, i.p., six times hourly).Swiss albino male induced Mice under oxidative stress (age: 6–8 weeks, body weight: 20–25 g) [1]. The expression of TNF-α, IL-17, IL-6, and IL-1β is dose-dependently decreased by visnagin. Nuclear p65-NFκB levels are attenuated by it. By enhancing Nrf2 expression, visnagin enhances antioxidant defense and suppresses pancreatic inflammation by preventing NFκB and nitrotyrosine expression in acinar cells [1].
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| References |
[1]. Radim Vrzal, et al. Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells. PLoS One. 2013 Sep 19;8(9):e74917.
[2]. Lakshmi Priya Pasari, et al. Visnagin attenuates acute pancreatitis via Nrf2/NFκB pathway and abrogates associated multiple organ dysfunction. Biomed Pharmacother. 2019 Apr;112:108629. |
| Molecular Formula |
C13H10O4
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|---|---|
| Molecular Weight |
230.2
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| Exact Mass |
230.06
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| Elemental Analysis |
C, 67.82; H, 4.38; O, 27.80
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| CAS # |
82-57-5
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| Appearance |
Solid powder
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| SMILES |
O=C1C=C(OC2=C1C(OC)=C3C=COC3=C2)C
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| InChi Key |
NZVQLVGOZRELTG-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C13H10O4/c1-7-5-9(14)12-11(17-7)6-10-8(3-4-16-10)13(12)15-2/h3-6H,1-2H3
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| Chemical Name |
4-methoxy-7-methyl-5H-furo[3,2-g]chromen-5-one
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| Synonyms |
NSC100593; Visnagin; NSC-100593; NSC 100593
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~217.18 mM)
Ethanol :< 1 mg/mL DMF :< 1 mg/mL |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (10.86 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.3440 mL | 21.7202 mL | 43.4405 mL | |
| 5 mM | 0.8688 mL | 4.3440 mL | 8.6881 mL | |
| 10 mM | 0.4344 mL | 2.1720 mL | 4.3440 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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