Size | Price | Stock | Qty |
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100mg |
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250mg |
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500mg |
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1g |
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2g |
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Other Sizes |
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Purity: ≥98%
Vonoprazan Fumarate (formerly TAK-438, TAK 438, trade name Takecab), the fumarate salt of Vonoprazan, is a novel, orally bioactive and potent P-CAB (potassium-competitive acid blocker) that has been approved in Janpan in 2015 for the treatment of gastroduodenal ulcer and reflux esophagitis. It acts by reversibly inhibiting H+/K+, ATPase with an IC50 of 19 nM (pH 6.5), controls gastric acid secretion. In cultured gastric glands, TAK-438 treatment resulted in a longer and stronger acid formation inhibition. The inhibition effect of TAK-438 on acid secretion seemed to be associated with gastric parietal cell physiology.
ln Vitro |
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ln Vivo |
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Animal Protocol |
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References |
J Pharmacol Exp Ther.2010 Oct;335(1):231-8;J Pharmacol Exp Ther.2011 Jun;337(3):797-804.
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Molecular Formula |
C17H16FN3O2S.C4H4O4
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Molecular Weight |
461.46
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CAS # |
1260141-27-2
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Related CAS # |
881681-00-1;1260141-27-2 (fumarate);1260141-27-2;
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
FC(C=CC=C1)=C1C2=CC(CNC)=CN2S(=O)(C3=CC=CN=C3)=O.OC(/C=C/C(O)=O)=O
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Synonyms |
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.1670 mL | 10.8352 mL | 21.6704 mL | |
5 mM | 0.4334 mL | 2.1670 mL | 4.3341 mL | |
10 mM | 0.2167 mL | 1.0835 mL | 2.1670 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.