| Size | Price | Stock | Qty |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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WM-8014 (WM8014; MOZ-IN3; MOZ-IN-3) is a novel, potent and prototypical inhibitor of MOZ (IC50 = 55 nM) which is a member of histone acetyltransferases with anticancer activity. It is also a highly potent inhibitor of KAT6A with IC50 of 0.008 μM. WM-8014 competes with acetyl-CoA (Ac-CoA) for binding to the Ac-CoA binding site.
| ln Vitro |
WM-8014 (Compound 36) has an IC50 of 55 nM, making it an inhibitor of MOZ. With an IC50 of 1.6 μM and 551 nM, respectively, WM-8014 suppresses proliferation and induces cell senescence. Additionally, WM-8014 decreased the MOZ gene Cdc6's mRNA encoding by 65.1%[1].
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| References |
| Molecular Formula |
C20H17FN2O3S
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|---|---|
| Molecular Weight |
384.423987150192
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| Exact Mass |
384.094
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| CAS # |
2055397-18-5
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| PubChem CID |
133053564
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| Appearance |
White to off-white solid powder
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| LogP |
4.1
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
27
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| Complexity |
595
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| Defined Atom Stereocenter Count |
0
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| SMILES |
S(C1C=CC=CC=1)(NNC(C1=C(C(C)=CC(C2C=CC=CC=2)=C1)F)=O)(=O)=O
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| InChi Key |
PHHZKBMVRPULAW-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C20H17FN2O3S/c1-14-12-16(15-8-4-2-5-9-15)13-18(19(14)21)20(24)22-23-27(25,26)17-10-6-3-7-11-17/h2-13,23H,1H3,(H,22,24)
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| Chemical Name |
[1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide
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| Synonyms |
WM-8014 MOZ-IN-3WM 8014 MOZ-IN 3WM8014 MOZ-IN3
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 250 mg/mL (~650.33 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.50 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6013 mL | 13.0066 mL | 26.0132 mL | |
| 5 mM | 0.5203 mL | 2.6013 mL | 5.2026 mL | |
| 10 mM | 0.2601 mL | 1.3007 mL | 2.6013 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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