| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| Other Sizes |
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| ln Vivo |
A possible endogenous class II metabotropic glutamate receptor agonist that influences thalamic sensory transmission is xanthurenic acid. During iontophoresis and intravenous injection, xanthuric acid (XA) causes sensory suppression. Like other group II mGlu receptor agonists, XA also lessens the suppression caused by physiological sensory input in the thalamic reticular nucleus VB. Furthermore, xanthine acid is thought to be the first possible endogenous mGlu receptor allosteric agonist. Xanthophoric acid, a potential endotoxin that represents both the kynurenine metabolic pathway and class II receptors, is important for studying antipsychotics because these two pathways are closely linked to the pathophysiology of schizophrenia [1]. The combination of these two pathways represents a novel class II receptor ligand.
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| References |
[1]. Copeland CS, et al. Actions of Xanthurenic acid, a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus. Neuropharmacology. 2013 Mar;66:133-42
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| Molecular Formula |
C10H7NO4
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|---|---|
| Molecular Weight |
205.1669
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| CAS # |
59-00-7
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| Related CAS # |
Xanthurenic acid-d4;1329611-28-0
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| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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| SMILES |
O([H])C1=C([H])C([H])=C([H])C2C(C([H])=C(C(=O)O[H])N([H])C=21)=O
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~8.93 mg/mL (~43.52 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 20 mg/mL (97.48 mM) in 50% PEG300 +50% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.8740 mL | 24.3700 mL | 48.7401 mL | |
| 5 mM | 0.9748 mL | 4.8740 mL | 9.7480 mL | |
| 10 mM | 0.4874 mL | 2.4370 mL | 4.8740 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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