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    Z-DEVD-FMK
    Z-DEVD-FMK

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0029
    CAS #: 210344-95-9Purity ≥98%

    Description: Z-DEVD-FMK, a tetrapeptide, is a novel, potent, specific and irreversible caspase-3 inhibitor with IC50 of 18 μM. It is considered to be relatively selective for caspase-3 and has been widely used in in vitro and in vivo models of acute injury to delineate roles for caspase 3 in neuronal cell death. Intracerebroventricular injections of Z-DEVD-FMK improved function after LFP. Intraparenchymal infusion of Z-DEVD-FMK over several days after combined CCI and hypoxia reduced lesion size, although functional outcome was not significantly improved in this model.

    Reference:  Eur J Immunol. 1998 Jan;28(1):296-304; J Neurosci. 1997 Oct 1;17(19):7415-24.


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    Molecular Weight (MW)668.66
    FormulaC30H41FN4O12
    CAS No.210344-95-9
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (149.55 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: methyl (5S,8S,11S,14S)-14-(2-fluoroacetyl)-11-isopropyl-5-(2-methoxy-2-oxoethyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate

    InChi Key: GBJVAVGBSGRRKN-JYEBCORGSA-N

    InChi Code: InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1

    SMILES Code: O=C(OC)CC[[email protected]](NC([[email protected]@H](NC(OCC1=CC=CC=C1)=O)CC(OC)=O)=O)C(N[[email protected]@H](C(C)C)C(N[[email protected]](C(CF)=O)CC(OC)=O)=O)=O

    SynonymsL-Valinamide, N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester; Z-DEVD-fmk; Z DEVD fmk; ZDEVDfmk


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    In VitroZ-DEVD-FMK (1–200 μM) inhibits D4-GDI cleavage and apoptosis in a concentration-dependent manner. Z-DEVD-FMK reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. Z-DEVD-FMK (100 μM) blocks MPP+-induced increases in caspase-3 enzyme activity. Z-DEVD-FMK dose dependently blocks 6-OHDA-induced apoptotic cell death with IC50 of 18 μM.
    In VivoZ-DEVD-FMK, before and after injury, markedly reduces post-traumatic apoptosis, and significantly improved neurological recovery
    Animal modelMale Sprague Dawley rats with Brain trauma.
    Formulation & DosageDMSO; 160 ng; Intracerebroventricular administration
    References[1] Rickers A, et al. Eur J Immunol. 1998, (1), 296-304.[2] Yakovlev AG, et al. J Neurosci. 1997, 17(19), 7415-7424.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     

    Z-DEVD-FMK

     

    Z-DEVD-FMK

     

    Z-DEVD-FMK


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