• Other

    Other
  • CN

    CN
  • EU

    EU
  • USA

    USA
    • My cart
    In the shopping cart is not goods, to choose and buy!
    • Product Name
    • Size
    • Quantity
    • Amount
      Selected items : 0 pieces Total : CHECK OUT()
      Z-IETD-FMK
      Z-IETD-FMK

      Price：
      Market Price：

      This product is for research use only, not for human use. We do not sell to patients.
      Number： - + Pieces（InventoryPieces）
      InvivoChem Cat #: V0030
      CAS #: 210344-98-2Purity ≥98%

      Description: Z-IETD-FMK (also known as Z-IE(OMe)TD(OMe)-FMK) is a novel, specific, selective, irreversible and cell permeable Caspase-8/9 inhibitor. Z-IETD-FMK inhibits T cell proliferation induced by PHA or anti-CD3 plus anti-CD28 without toxicity of resting T cells. The mechanism of this inhibition of Z-IETD-FMK has been proved not through the effect on IL-2 secretion or IFN-γ production but the decrease of CD25 expression. Experiments show that Z-IETD-FMK has no effect on normal cell growth when there is no activation signal. Z-IETD-FMK has also been found to significantly inhibit NF-κB activation when the concentration is 100μM. Apart from the ability of inhibiting cell proliferation, Z-IETD-FMK is reported to inhibit TRAIL-mediated killing in cells. It protects the procaspases 9, 2, and 3, and protects PARP to a similar extent in both HCT116 and SW480 cells.

      References: Toxicol Appl Pharmacol. 2012 Nov 15;265(1):103-12; Cancer Res. 2000 Nov 15;60(22):6259-65.


      Customer Validation
      Official Supplier of
      • VE
      • OF
      • YALE
      • hhmi
      • 香港大学
      Related Products
      Publications Citing InvivoChem Products
      • Physicochemical and Storage Information
      • Protocol
      • Quality Control Documentation
      • Related Biological Data
      • Customer Review
      Molecular Weight (MW)654.68
      FormulaC30H43FN4O11
      CAS No.210344-98-2
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 91 mg/mL (138.99 mM)
      Water:<1 mg/mL (slightly soluble or insoluble)
      Ethanol: <1 mg/mL
      Other info

      Synonym: Z-IE(OMe)TD(OMe)-FMK; Granzyme B Inhibitor III; Z-IETD-FMK; Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F.

      Chemical Name: (5S,8S,11S,14S)-5-((S)-sec-butyl)-8-(2-carboxyethyl)-14-(2-fluoroacetyl)-11-((R)-1-hydroxyethyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oic acid

      InChi Key: CTXDBLYOEUERAT-VUVYEONESA-N

      InChi Code: InChI=1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1

      SMILES Code: O=C(O)C[[email protected]@H](C(CF)=O)NC([[email protected]]([[email protected]](O)C)NC([[email protected]](CCC(O)=O)NC([[email protected]]([[email protected]@H](C)CC)NC(OCC1=CC=CC=C1)=O)=O)=O)=O

      Chemical NameL-Threoninamide, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester


      • Molarity Calculator
      • Dilution Calculator
      • The molarity calculator equation

        Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

        • Mass
        • Concentration
        • Volume
        • Molecular Weight *
        • =
        • ×
        • ×
      • The dilution calculator equation

        Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

        This equation is commonly abbreviated as: C1V1 = C2V2

        • Concentration (start)
        • ×
        • Volume (start)
        • =
        • Concentration (final)
        • ×
        • Volume (final)
        • ×
        • =
        • ×
        • C1
        •  
        • V1
        •  
        • C2
        •  
        • V2
      In VitroZ-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli. Z-IETD-FMK (50 μM) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3.
      In VivoIn vivo, inhibition of caspase-8 by Z-IETD-FMK reduces memory/activated CD4 and CD8 T cells, and increases susceptibility to T. cruzi infection. Z-IETD-FMK promotes neuronal survival and regeneration of injured retinal ganglion cells after CNS injuries.
      Animal modelT. cruzi-infected mice
      Formulation & Dosage DMSO/PBS (15%); 0.4 mg/3 days
      References[1] Silva EM, et al. J Immunol. 2005, 174(10), 6314-6321.  [2] Monnier PP, et al. J Neurosci. 2011, 31(29), 10494-10505.

      These protocols are for reference only. InvivoChem does not independently validate these methods.

       

      Z-IETD-FMK

      		 

      Z-IETD-FMK

      		 

      Z-IETD-FMK

      Caspase-8 and caspase-3 processing in newly activated T cells without apoptotic phenotype. Toxicol Appl Pharmacol. 2012 Nov 15;265(1):103-12. 

      评论

        Home Prev Next Last page / pices

        发评论

        ×
        Your information is safe with us. * Required Fields.
        Products are for research use only;  We do not sell to patients
        Contact Us
        Contact Us
        Tel: 1-708-310-1919
        Fax: 1-708-557-7486
        Email: [email protected]
        Frequently Asked Questions
        Subscribe to our E-newsletter
        • Name*
        • *
        • E-mail*
        • *
        • instructions：
        • *
        Copyright 2020 InvivoChem LLC | All Rights Reserved
          Site map
        prompt
        Do you confirm the receipt?