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Purity: ≥98%
Z-VAD-FMK (Caspase Inhibitor VI; Z-VAD(OH)-FMK) is a novel, potent and irreversible pan caspase inhibitor. For in vitro studies, there is no need for a pretreatment with esterase. Z-VAD(OH)-FMK, which is not methylated, is a form of Z-VAD-FMK that is helpful in studies involving recombinant or purified enzymes.
| Targets |
Caspase
|
|---|---|
| ln Vitro |
Z-VAD(OH)-FMK, which is not methylated, is a form of Z-VAD-FMK that is helpful in studies involving recombinant or purified enzymes. [1]
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| ln Vivo |
Z-VAD-FMK, a widely used broad-spectrum caspase inhibitor, repairs muscle damage brought on by compression and preserves muscle function.
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| Cell Assay |
Cells were treated with indicated concentration of the drug for an hour.
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| Animal Protocol |
Male BALB/C mice
1.5 mg/kg s.c. |
| References |
| Molecular Formula |
C21H28FN3O7
|
|---|---|
| Molecular Weight |
453.46
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| Exact Mass |
453.1911
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| Elemental Analysis |
C, 55.62; H, 6.22; F, 4.19; N, 9.27; O, 24.70
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| CAS # |
161401-82-7
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| Related CAS # |
Z-VAD(OMe)-FMK;187389-52-2
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| Appearance |
Solid powder
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| SMILES |
C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
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| InChi Key |
SUUHZYLYARUNIA-YEWWUXTCSA-N
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| InChi Code |
InChI=1S/C21H28FN3O7/c1-12(2)18(25-21(31)32-11-14-7-5-4-6-8-14)20(30)23-13(3)19(29)24-15(9-17(27)28)16(26)10-22/h4-8,12-13,15,18H,9-11H2,1-3H3,(H,23,30)(H,24,29)(H,25,31)(H,27,28)/t13-,15-,18-/m0/s1
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| Chemical Name |
(3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-4-oxopentanoic acid
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| Synonyms |
Z-Val-Ala-Asp-(OH)-Fluoromethyl Ketone; Z-VAD(OH)-FMK
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 90~100 mg/mL (198.5~220.5 mM)
Ethanol: ~90 mg/mL (~198.5 mM) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2053 mL | 11.0263 mL | 22.0527 mL | |
| 5 mM | 0.4411 mL | 2.2053 mL | 4.4105 mL | |
| 10 mM | 0.2205 mL | 1.1026 mL | 2.2053 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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