| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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ZM 39923 HCl, the hydrochloride salt of ZM-39923, is a novel and potent inhibitor of Janus kinase-JAK1/3 with potential anti-inflammatory activity. It inhibits JAK1/3 with pIC50s of 4.4/7.1, and shows little/no activity against JAK2 and modestly potency to EGFR; also found to be sensitive to transglutaminase.
| ln Vitro |
ZM39923 hydrochloride has a pIC50 of 7.1, making it a JAK3 inhibitor. ZM39923 (Compound 7) inhibits tyrosine kinases Lck and CDK4 (pIC50 <5.0) and EGF-R and JAK1 (pIC50, 5.6, and 4.4, respectively) with a modest inhibitory effect[1]. ZM39923 acts directly on pure TGM2 to inhibit the Ca2+ activated form of TGM2, and it potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM[2]. ZM39923 inhibits JAK3 phosphorylation brought on by CCL19; this action is comparable to that of an anti-CCR7 antibody. ZM39923 also dramatically reduces PCI-37B cell migration and invasion and prevents the CCL19-induced wound closure rate[3].
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| ln Vivo |
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| Animal Protocol |
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| References |
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| Molecular Formula |
C23H25NO.HCL
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| Molecular Weight |
367.91
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| Exact Mass |
367.17
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| CAS # |
1021868-92-7
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| Related CAS # |
ZM39923;273727-89-2
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| PubChem CID |
176406
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| Appearance |
White to off-white solid powder
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| LogP |
6.955
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
26
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| Complexity |
412
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
NJTUORMLOPXPBY-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C23H25NO.ClH/c1-18(2)24(17-19-8-4-3-5-9-19)15-14-23(25)22-13-12-20-10-6-7-11-21(20)16-22;/h3-13,16,18H,14-15,17H2,1-2H3;1H
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| Chemical Name |
3-[benzyl(propan-2-yl)amino]-1-naphthalen-2-ylpropan-1-one;hydrochloride
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| Synonyms |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.80 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (6.80 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (6.80 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7181 mL | 13.5903 mL | 27.1806 mL | |
| 5 mM | 0.5436 mL | 2.7181 mL | 5.4361 mL | |
| 10 mM | 0.2718 mL | 1.3590 mL | 2.7181 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Ca+2-dependent Inhibition of TGase/TGM2 by chemical inhibitors.Chem Biol.2008 Sep 22;15(9):969-78. |
Fluorescent GTP Binding Assay.Chem Biol.2008 Sep 22;15(9):969-78. |
Effects of chemical inhibitors in rescuing Drosophila in HD model of neurodegeneration.Chem Biol.2008 Sep 22;15(9):969-78. |
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