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Zoniporide (CP-597396) HCl hydrate is a novel highly potent and specific inhibitor of sodium-hydrogen exchanger type 1 (NHE-1) with cardioprotective effects against myocardial injuries and ischemic insults. Zoniporide HCl hydrate inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide HCl hydrate highly potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM).
| ln Vivo |
Zonipol hydrochloride hydrate (0.25-4 mg/kg; intravenously; once hourly for 2 hours) causes a dose-dependent reduction in infarct size in rabbits under thoracotomy anesthesia (ED50=0.45 mg/kg/ h)[1]. Zoniporide exhibits moderate plasma protein binding with a t1/2 of 1.5 hours in monkeys and has one major active metabolite [1]. Zonipol hydrochloride hydrate treatment showed AUC0-∞ and t1/2 of 0.07 μg·h/mL and 0.5 hours respectively [2].
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| Animal Protocol |
Animal/Disease Models: Rabbit [1]
Doses: 0.25, 1, 4 mg/kg Route of Administration: once every hour for 2 hrs (hrs (hours)); intravenous (iv) (iv)injection Experimental Results: There was a significant dose-dependent reduction in infarct area in anesthetized rabbits. ED50 is 0.45 mg/kg/h. Animal/Disease Models: Rat [2] Doses: 1 mg/kg Route of Administration: intravenous (iv) (iv)injection (pharmacokinetic/PK/PK analysis) Experimental Results: AUC0-∞ and t1/2 were 0.07 μg·h/mL and 0.5 hrs (hrs (hours)) respectively. |
| References |
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| Molecular Formula |
C₁₇H₁₉CLN₆O₂
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|---|---|
| Molecular Weight |
374.82
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| Exact Mass |
374.126
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| CAS # |
863406-85-3
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| Related CAS # |
Zoniporide hydrochloride;241800-97-5
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| PubChem CID |
22267662
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| Appearance |
White to off-white solid powder
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| LogP |
4.033
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
26
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| Complexity |
515
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
UCIJUEGJEFJRMP-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C17H16N6O.ClH.H2O/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H;1H2
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| Chemical Name |
5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide;hydrate;hydrochloride
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| Synonyms |
CP597396 CP-597396CP 597396
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~2 mg/mL (~5.34 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6679 mL | 13.3397 mL | 26.6795 mL | |
| 5 mM | 0.5336 mL | 2.6679 mL | 5.3359 mL | |
| 10 mM | 0.2668 mL | 1.3340 mL | 2.6679 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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